dorsal/arxiv
View SchemaA Physical Theory of the Competition that Allows HIV to Escape from the Immune System
| Authors | Guanyu Wang, Michael W. Deem |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0610018 |
| URL | https://arxiv.org/abs/q-bio/0610018 |
| DOI | 10.1103/PhysRevLett.97.188106 |
Abstract
Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The analytical model reproduces the three stages of HIV-1 infection. We propose a vaccine regimen that may be able to reduce competition between T cells, potentially eliminating the third stage of HIV-1.
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"abstract": "Competition within the immune system may degrade immune control of viral\ninfections. We formalize the evolution that occurs in both HIV-1 and the immune\nsystem quasispecies. Inclusion of competition in the immune system leads to a\nnovel balance between the immune response and HIV-1, in which the eventual\noutcome is HIV-1 escape rather than control. The analytical model reproduces\nthe three stages of HIV-1 infection. We propose a vaccine regimen that may be\nable to reduce competition between T cells, potentially eliminating the third\nstage of HIV-1.",
"arxiv_id": "q-bio/0610018",
"authors": [
"Guanyu Wang",
"Michael W. Deem"
],
"categories": [
"q-bio.PE"
],
"doi": "10.1103/PhysRevLett.97.188106",
"title": "A Physical Theory of the Competition that Allows HIV to Escape from the Immune System",
"url": "https://arxiv.org/abs/q-bio/0610018"
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