dorsal/arxiv
View SchemaDynamic re-wiring of protein interaction: The case of transactivation
| Authors | Gabriele Scheler |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0609014 |
| URL | https://arxiv.org/abs/q-bio/0609014 |
Abstract
We are looking at local protein interaction networks from the perspective of directed, labeled graphs with quantitative values for monotonic changes in concentrations. These systems can be used to perform stability analysis for a stable attractor, given initial values. They can also show re-configuration of whole system states by dynamic insertion of links, given specific patterns of input. The latter issue seems particularly relevant for the concept of multistability in cellular memory. We attempt to show that this level of analysis is well-suited for a number of relevant biological subsystems, such as transactivation in cardiac myocytes or G-protein coupling to adrenergic receptors. In particular, we analyse the 'motif' of an "overflow gate" as a concentration-dependent system reconfiguration.
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"abstract": "We are looking at local protein interaction networks from the perspective of\ndirected, labeled graphs with quantitative values for monotonic changes in\nconcentrations. These systems can be used to perform stability analysis for a\nstable attractor, given initial values. They can also show re-configuration of\nwhole system states by dynamic insertion of links, given specific patterns of\ninput. The latter issue seems particularly relevant for the concept of\nmultistability in cellular memory. We attempt to show that this level of\nanalysis is well-suited for a number of relevant biological subsystems, such as\ntransactivation in cardiac myocytes or G-protein coupling to adrenergic\nreceptors. In particular, we analyse the \u0027motif\u0027 of an \"overflow gate\" as a\nconcentration-dependent system reconfiguration.",
"arxiv_id": "q-bio/0609014",
"authors": [
"Gabriele Scheler"
],
"categories": [
"q-bio.MN"
],
"title": "Dynamic re-wiring of protein interaction: The case of transactivation",
"url": "https://arxiv.org/abs/q-bio/0609014"
},
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