{
  "annotation_id": "cd9d01aa-57e7-4346-90fd-71d0bcade0b4",
  "date_created": "2026-03-02T18:01:32.337000Z",
  "date_modified": "2026-03-02T18:01:32.337000Z",
  "file_hash": "ce5fad898d40d587e98051fda44a2b65f83a1b0669e45e4a52b05380f945a96f",
  "private": false,
  "record": {
    "abstract": "In this paper we use a continuous model to describe the development of a\nsingle cell lineage following the committal of stem cells. Three separate\ncontrols are implemented in the model, namely the proliferative control of stem\ncells, the proliferative control of developing blast cells, and the peripheral\ncontrol of stem cell committal by circulating blood cell density. We show that\nvariation of parameters in all three control systems can cause oscillations,\nand that the characters of these oscillations are very different. This allows\nus some potential insight into the mechanisms that may be operative in some of\nthe dynamic blood diseases like cyclical neutropenia and periodic chronic\nmyelogenous leukemia.",
    "arxiv_id": "q-bio/0409003",
    "authors": [
      "Ivana Drobnjak",
      "A. C. Fowler",
      "Michael C. Mackey"
    ],
    "categories": [
      "q-bio.TO"
    ],
    "title": "Oscillations in a maturation model of blood cell production",
    "url": "https://arxiv.org/abs/q-bio/0409003"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "3e4aca9f-426a-4005-8104-8882069751bd",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}