dorsal/arxiv
View SchemaMultiple Thresholds in a Model System of Noisy Ion Channels
| Authors | Michael J. Barber, Manfred L. Ristig |
|---|---|
| Categories | |
| ArXiv ID | physics/0602158 |
| URL | https://arxiv.org/abs/physics/0602158 |
| DOI | 10.1103/PhysRevE.74.041913 |
| Journal | Phys. Rev. E 74, 041913 (2006) |
Abstract
Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model. The enhancement occurs in a finite range of signals; the range can be extended using populations of channels. The range increases more rapidly in multiple-threshold channel populations than in single-threshold populations. The diversity of ion channels may thus be present as a strategy to reduce the metabolic costs of handling a broad class of electrochemical signals.
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"abstract": "Voltage-activated ion channels vary randomly between open and closed states,\ninfluenced by the membrane potential and other factors. Signal transduction is\nenhanced by noise in a simple ion channel model. The enhancement occurs in a\nfinite range of signals; the range can be extended using populations of\nchannels. The range increases more rapidly in multiple-threshold channel\npopulations than in single-threshold populations. The diversity of ion channels\nmay thus be present as a strategy to reduce the metabolic costs of handling a\nbroad class of electrochemical signals.",
"arxiv_id": "physics/0602158",
"authors": [
"Michael J. Barber",
"Manfred L. Ristig"
],
"categories": [
"physics.bio-ph"
],
"doi": "10.1103/PhysRevE.74.041913",
"journal_ref": "Phys. Rev. E 74, 041913 (2006)",
"title": "Multiple Thresholds in a Model System of Noisy Ion Channels",
"url": "https://arxiv.org/abs/physics/0602158"
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