{
  "annotation_id": "cd23a1d3-a7ca-486c-8a32-538819a380a5",
  "date_created": "2026-03-02T18:01:30.961000Z",
  "date_modified": "2026-03-02T18:01:30.961000Z",
  "file_hash": "e61fdb0b8e6a60c2a7b3c37ed32ca0c930b8a98df2ddcd8c7ebc880790596896",
  "private": false,
  "record": {
    "abstract": "To test whether X-chromosome has unique genomic characteristics, X-chromosome\nand 22 autosomes were compared for RNA binding density. Nucleotide sequences on\nthe chromosomes were divided into 50kb per segment that was recoded as a set of\nfrequency values of 7-nucleotide (7nt) strings using all possible 7nt strings\n(47=16384). 120 genes highly expressed in tonsil germinal center B cells were\nselected for calculating 7nt string frequency values of all introns (RNAs). The\nbinding density of DNA segments and RNAs was determined by the amount of\ncomplement sequences. It was shown for the first time that gene-poor and low\ngene expression X-chromosome had the lowest percentage of the DNA segments that\ncan highly bind RNAs, whereas gene-rich and high gene expression chromosome 19\nhad the highest percentage of the segments. On the basis of these results, it\nis proposed that the nonrandom properties of distribution of RNA highly binding\nDNA segments on the chromosomes provide strong evidence that lack of RNA highly\nbinding segments may be a cause of X-chromosome inactivation",
    "arxiv_id": "q-bio/0312039",
    "authors": [
      "Zhanjun Lu",
      "Ying Lu",
      "Shuxia Song",
      "Zhai Yu",
      "Xiufang Wang"
    ],
    "categories": [
      "q-bio.GN"
    ],
    "title": "RNA Binding Density on X-chromosome Differing from that on 22 Autosomes   in Human",
    "url": "https://arxiv.org/abs/q-bio/0312039"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "df280caf-014a-43bc-9a49-5841a2592920",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}