dorsal/arxiv
View SchemaMorphogen Gradient from a Noisy Source
| Authors | Jeremy L. England, John Cardy |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0502036 |
| URL | https://arxiv.org/abs/q-bio/0502036 |
| DOI | 10.1103/PhysRevLett.94.078101 |
| Journal | PRL 94, 078101 (2005) |
Abstract
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.
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"abstract": "We investigate the effect of time-dependent noise on the shape of a morphogen\ngradient in a developing embryo. Perturbation theory is used to calculate the\ndeviations from deterministic behavior in a simple reaction-diffusion model of\nrobust gradient formation, and the results are confirmed by numerical\nsimulation. It is shown that such deviations can disrupt robustness for\nsufficiently high noise levels, and the implications of these findings for more\ncomplex models of gradient-shaping pathways are discussed.",
"arxiv_id": "q-bio/0502036",
"authors": [
"Jeremy L. England",
"John Cardy"
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"doi": "10.1103/PhysRevLett.94.078101",
"journal_ref": "PRL 94, 078101 (2005)",
"title": "Morphogen Gradient from a Noisy Source",
"url": "https://arxiv.org/abs/q-bio/0502036"
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