{
  "annotation_id": "ca5b939d-90e0-4ea9-8ffe-6782a7e2d668",
  "date_created": "2026-03-02T18:01:31.529000Z",
  "date_modified": "2026-03-02T18:01:31.529000Z",
  "file_hash": "ab5eed299e32d6721c341ee818eea0982e785d2d40ef1ce11f8cdfd52d8e4f31",
  "private": false,
  "record": {
    "abstract": "We investigate the effect of time-dependent noise on the shape of a morphogen\ngradient in a developing embryo. Perturbation theory is used to calculate the\ndeviations from deterministic behavior in a simple reaction-diffusion model of\nrobust gradient formation, and the results are confirmed by numerical\nsimulation. It is shown that such deviations can disrupt robustness for\nsufficiently high noise levels, and the implications of these findings for more\ncomplex models of gradient-shaping pathways are discussed.",
    "arxiv_id": "q-bio/0502036",
    "authors": [
      "Jeremy L. England",
      "John Cardy"
    ],
    "categories": [
      "q-bio.TO",
      "cond-mat.other",
      "q-bio.MN",
      "q-bio.OT"
    ],
    "doi": "10.1103/PhysRevLett.94.078101",
    "journal_ref": "PRL 94, 078101 (2005)",
    "title": "Morphogen Gradient from a Noisy Source",
    "url": "https://arxiv.org/abs/q-bio/0502036"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "cfa01b7d-d152-4526-a2d3-b8140daf931f",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}