dorsal/arxiv
View SchemaGenetic Regulation of Fluxes: Iron Homeostasis of Escherichia coli
| Authors | Szabolcs Semsey, Anna M. C. Andersson, Sandeep Krishna, Mogens H Jensen, Eric Massé, Kim Sneppen |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0609042 |
| URL | https://arxiv.org/abs/q-bio/0609042 |
Abstract
Iron is an essential trace-element for most organisms. However, because high concentration of free intracellular iron is cytotoxic, cells have developed complex regulatory networks that keep free intracellular iron concentration at optimal range, allowing the incorporation of the metal into iron-using enzymes and minimizing damage to the cell. We built a mathematical model of the network that controls iron uptake and usage in the bacterium Escherichia coli to explore the dynamics of iron flow. We simulate the effect of sudden decrease or increase in the extracellular iron level on intracellular iron distribution. Based on the results of simulations we discuss the possible roles of the small RNA RyhB and the Fe-S cluster assembly systems in the optimal redistribution of iron flows. We suggest that Fe-S cluster assembly is crucial to prevent the accumulation of toxic levels of free intracellular iron when the environment suddenly becomes iron rich.
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"abstract": "Iron is an essential trace-element for most organisms. However, because high\nconcentration of free intracellular iron is cytotoxic, cells have developed\ncomplex regulatory networks that keep free intracellular iron concentration at\noptimal range, allowing the incorporation of the metal into iron-using enzymes\nand minimizing damage to the cell. We built a mathematical model of the network\nthat controls iron uptake and usage in the bacterium Escherichia coli to\nexplore the dynamics of iron flow. We simulate the effect of sudden decrease or\nincrease in the extracellular iron level on intracellular iron distribution.\nBased on the results of simulations we discuss the possible roles of the small\nRNA RyhB and the Fe-S cluster assembly systems in the optimal redistribution of\niron flows. We suggest that Fe-S cluster assembly is crucial to prevent the\naccumulation of toxic levels of free intracellular iron when the environment\nsuddenly becomes iron rich.",
"arxiv_id": "q-bio/0609042",
"authors": [
"Szabolcs Semsey",
"Anna M. C. Andersson",
"Sandeep Krishna",
"Mogens H Jensen",
"Eric Mass\u00e9",
"Kim Sneppen"
],
"categories": [
"q-bio.MN"
],
"title": "Genetic Regulation of Fluxes: Iron Homeostasis of Escherichia coli",
"url": "https://arxiv.org/abs/q-bio/0609042"
},
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