dorsal/arxiv
View SchemaEvolution at the Edge of Chaos: A Paradigm for the Maturation of the Humoral Immune Response
| Authors | Patricia Theodosopoulos, Ted Theodosopoulos |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0406014 |
| URL | https://arxiv.org/abs/q-bio/0406014 |
| Journal | Evolution as Computation, Springer Natural Computing Series, Landweber and Winfree eds., 2002, pp. 41-66 |
Abstract
We study the maturation of the antibody population following primary antigen presentation as a global optimization problem. Emphasis is placed on the trade-off between the safety of mutations that lead to local improvements to the antibody's affinity and the necessity of eventual mutations that result in global reconfigurations in the antibody's shape. The model described herein gives evidence of the underlying optimization process from which the rapidity and consistency of the biologic response could be derived.
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"abstract": "We study the maturation of the antibody population following primary antigen\npresentation as a global optimization problem. Emphasis is placed on the\ntrade-off between the safety of mutations that lead to local improvements to\nthe antibody\u0027s affinity and the necessity of eventual mutations that result in\nglobal reconfigurations in the antibody\u0027s shape. The model described herein\ngives evidence of the underlying optimization process from which the rapidity\nand consistency of the biologic response could be derived.",
"arxiv_id": "q-bio/0406014",
"authors": [
"Patricia Theodosopoulos",
"Ted Theodosopoulos"
],
"categories": [
"q-bio.QM",
"q-bio.PE"
],
"journal_ref": "Evolution as Computation, Springer Natural Computing Series,\n Landweber and Winfree eds., 2002, pp. 41-66",
"title": "Evolution at the Edge of Chaos: A Paradigm for the Maturation of the Humoral Immune Response",
"url": "https://arxiv.org/abs/q-bio/0406014"
},
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