dorsal/arxiv
View SchemaForce Modulating Dynamic Disorder: Physical Theory of Catch-slip bond Transitions in Receptor-Ligand Forced Dissociation Experiments
| Authors | Fei Liu, Zhong-can Ou-Yang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0601017 |
| URL | https://arxiv.org/abs/q-bio/0601017 |
| DOI | 10.1103/PhysRevE.74.051904 |
Abstract
Recently experiments showed that some adhesive receptor-ligand complexes increase their lifetimes when they are stretched by mechanical force, while the force increase beyond some thresholds their lifetimes decrease. Several specific chemical kinetic models have been developed to explain the intriguing transitions from the "catch-bonds" to the "slip-bonds". In this work we suggest that the counterintuitive forced dissociation of the complexes is a typical rate process with dynamic disorder. An uniform one-dimension force modulating Agmon-Hopfield model is used to quantitatively describe the transitions observed in the single bond P-selctin glycoprotein ligand 1(PSGL-1)$-$P-selectin forced dissociation experiments, which were respectively carried out on the constant force [Marshall, {\it et al.}, (2003) Nature {\bf 423}, 190-193] and the force steady- or jump-ramp [Evans {\it et al.}, (2004) Proc. Natl. Acad. Sci. USA {\bf 98}, 11281-11286] modes. Our calculation shows that the novel catch-slip bond transition arises from a competition of the two components of external applied force along the dissociation reaction coordinate and the complex conformational coordinate: the former accelerates the dissociation by lowering the height of the energy barrier between the bound and free states (slip), while the later stabilizes the complex by dragging the system to the higher barrier height (catch).
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"abstract": "Recently experiments showed that some adhesive receptor-ligand complexes\nincrease their lifetimes when they are stretched by mechanical force, while the\nforce increase beyond some thresholds their lifetimes decrease. Several\nspecific chemical kinetic models have been developed to explain the intriguing\ntransitions from the \"catch-bonds\" to the \"slip-bonds\". In this work we suggest\nthat the counterintuitive forced dissociation of the complexes is a typical\nrate process with dynamic disorder. An uniform one-dimension force modulating\nAgmon-Hopfield model is used to quantitatively describe the transitions\nobserved in the single bond P-selctin glycoprotein ligand\n1(PSGL-1)$-$P-selectin forced dissociation experiments, which were respectively\ncarried out on the constant force [Marshall, {\\it et al.}, (2003) Nature {\\bf\n423}, 190-193] and the force steady- or jump-ramp [Evans {\\it et al.}, (2004)\nProc. Natl. Acad. Sci. USA {\\bf 98}, 11281-11286] modes. Our calculation shows\nthat the novel catch-slip bond transition arises from a competition of the two\ncomponents of external applied force along the dissociation reaction coordinate\nand the complex conformational coordinate: the former accelerates the\ndissociation by lowering the height of the energy barrier between the bound and\nfree states (slip), while the later stabilizes the complex by dragging the\nsystem to the higher barrier height (catch).",
"arxiv_id": "q-bio/0601017",
"authors": [
"Fei Liu",
"Zhong-can Ou-Yang"
],
"categories": [
"q-bio.CB",
"q-bio.BM"
],
"doi": "10.1103/PhysRevE.74.051904",
"title": "Force Modulating Dynamic Disorder: Physical Theory of Catch-slip bond Transitions in Receptor-Ligand Forced Dissociation Experiments",
"url": "https://arxiv.org/abs/q-bio/0601017"
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