dorsal/arxiv
View SchemaZipf's Law in Gene Expression
| Authors | Chikara Furusawa, Kunihiko Kaneko |
|---|---|
| Categories | |
| ArXiv ID | physics/0209103 |
| URL | https://arxiv.org/abs/physics/0209103 |
| DOI | 10.1103/PhysRevLett.90.088102 |
Abstract
Using data from gene expression databases on various organisms and tissues, including yeast, nematodes, human normal and cancer tissues, and embryonic stem cells, we found that the abundances of expressed genes exhibit a power-law distribution with an exponent close to -1, i.e., they obey Zipf's law. Furthermore, by simulations of a simple model with an intra-cellular reaction network, we found that Zipf's law of chemical abundance is a universal feature of cells where such a network optimizes the efficiency and faithfulness of self-reproduction. These findings provide novel insights into the nature of the organization of reaction dynamics in living cells.
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"abstract": "Using data from gene expression databases on various organisms and tissues,\nincluding yeast, nematodes, human normal and cancer tissues, and embryonic stem\ncells, we found that the abundances of expressed genes exhibit a power-law\ndistribution with an exponent close to -1, i.e., they obey Zipf\u0027s law.\nFurthermore, by simulations of a simple model with an intra-cellular reaction\nnetwork, we found that Zipf\u0027s law of chemical abundance is a universal feature\nof cells where such a network optimizes the efficiency and faithfulness of\nself-reproduction. These findings provide novel insights into the nature of the\norganization of reaction dynamics in living cells.",
"arxiv_id": "physics/0209103",
"authors": [
"Chikara Furusawa",
"Kunihiko Kaneko"
],
"categories": [
"physics.bio-ph",
"cond-mat.dis-nn",
"nlin.AO",
"q-bio"
],
"doi": "10.1103/PhysRevLett.90.088102",
"title": "Zipf\u0027s Law in Gene Expression",
"url": "https://arxiv.org/abs/physics/0209103"
},
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