dorsal/arxiv
View SchemaMicroRNAs preferentially target the genes with high transcriptional regulation complexity
| Authors | Qinghua Cui, Zhenbao Yu, Youlian Pan, Enrico Purisima, Edwin Wang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0701001 |
| URL | https://arxiv.org/abs/q-bio/0701001 |
| DOI | 10.1016/j.bbrc.2006.11.080 |
| Journal | Biochem Biophys Res Commun., 352:733-738, 2007 |
Abstract
Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e. what principles govern miRNA regulation in animal genomes. In this study, we systematically analyzed the relationship between transcription factors (TFs) and miRNAs in gene regulation. We found that the genes with more TF-binding sites have a higher probability of being targeted by miRNAs and have more miRNA-binding sites on average. This observation reveals that the genes with higher cis-regulation complexity are more coordinately regulated by TFs at the transcriptional level and by miRNAs at the post-transcriptional level. This is a potentially novel discovery of mechanism for coordinated regulation of gene expression. Gene ontology analysis further demonstrated that such coordinated regulation is more popular in the developmental genes.
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"abstract": "Over the past few years, microRNAs (miRNAs) have emerged as a new prominent\nclass of gene regulatory factors that negatively regulate expression of\napproximately one-third of the genes in animal genomes at post-transcriptional\nlevel. However, it is still unclear why some genes are regulated by miRNAs but\nothers are not, i.e. what principles govern miRNA regulation in animal genomes.\nIn this study, we systematically analyzed the relationship between\ntranscription factors (TFs) and miRNAs in gene regulation. We found that the\ngenes with more TF-binding sites have a higher probability of being targeted by\nmiRNAs and have more miRNA-binding sites on average. This observation reveals\nthat the genes with higher cis-regulation complexity are more coordinately\nregulated by TFs at the transcriptional level and by miRNAs at the\npost-transcriptional level. This is a potentially novel discovery of mechanism\nfor coordinated regulation of gene expression. Gene ontology analysis further\ndemonstrated that such coordinated regulation is more popular in the\ndevelopmental genes.",
"arxiv_id": "q-bio/0701001",
"authors": [
"Qinghua Cui",
"Zhenbao Yu",
"Youlian Pan",
"Enrico Purisima",
"Edwin Wang"
],
"categories": [
"q-bio.GN",
"q-bio.MN"
],
"doi": "10.1016/j.bbrc.2006.11.080",
"journal_ref": "Biochem Biophys Res Commun., 352:733-738, 2007",
"title": "MicroRNAs preferentially target the genes with high transcriptional regulation complexity",
"url": "https://arxiv.org/abs/q-bio/0701001"
},
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