dorsal/arxiv
View SchemaAn Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21
| Authors | Wentian Li, Dirk Holste |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0411015 |
| URL | https://arxiv.org/abs/q-bio/0411015 |
| DOI | 10.1016/j.compbiolchem.2004.09.011 |
| Journal | Computational Biology and Chemistry, 28(5-6): 393-399 (2004) |
Abstract
An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys. The GC-poor valleys comprise regions with low density of CpG islands and, alternating between the two DNA strands, low gene density regions. Consequently, the long-range oscillation of GC% result in spacing patterns of both CpG island density, and to a lesser extent, gene densities.
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"abstract": "An oscillation with a period of around 500 kb in guanine and cytosine content\n(GC%) is observed in the DNA sequence of human chromosome 21. This oscillation\nis localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb\nto 46.5 Mb. Five cycles of oscillation are observed in this region with six\nGC-rich peaks and five GC-poor valleys. The GC-poor valleys comprise regions\nwith low density of CpG islands and, alternating between the two DNA strands,\nlow gene density regions. Consequently, the long-range oscillation of GC%\nresult in spacing patterns of both CpG island density, and to a lesser extent,\ngene densities.",
"arxiv_id": "q-bio/0411015",
"authors": [
"Wentian Li",
"Dirk Holste"
],
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"q-bio.GN",
"q-bio.QM"
],
"doi": "10.1016/j.compbiolchem.2004.09.011",
"journal_ref": "Computational Biology and Chemistry, 28(5-6): 393-399 (2004)",
"title": "An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21",
"url": "https://arxiv.org/abs/q-bio/0411015"
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