{
  "annotation_id": "c43ff74f-46b2-49fe-a433-ab77c36a8b41",
  "date_created": "2026-03-02T18:01:31.347000Z",
  "date_modified": "2026-03-02T18:01:31.347000Z",
  "file_hash": "c22584ec38f9b994c5784a04b5b5ceb597154702c1a62b746f7aef2aebf069b8",
  "private": false,
  "record": {
    "abstract": "Integrins mediate cell adhesion and are essential receptors for the\ndevelopment and functioning of multicellular organisms. Integrin activation is\nknown to require both ligand and talin binding and to correlate with cluster\nformation but the activation mechanism and precise roles of these processes are\nnot yet resolved. Here mathematical modeling, with known experimental\nparameters, is used to show that the binding of a stabilizing factor, such as\ntalin, is alone insufficient to enable ligand-dependent integrin activation for\nall observed conditions; an additional positive feedback is required.",
    "arxiv_id": "q-bio/0507010",
    "authors": [
      "Dagmar Iber",
      "Iain D Campbell"
    ],
    "categories": [
      "q-bio.MN",
      "q-bio.CB",
      "q-bio.SC"
    ],
    "doi": "10.1007/s11538-005-9049-5",
    "title": "Integrin activation - the importance of a positive feedback",
    "url": "https://arxiv.org/abs/q-bio/0507010"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "89f47fab-deb3-479e-b752-5f48f01a76f3",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}