{
  "annotation_id": "c3d992c7-bac2-4b32-925e-c440cfd706be",
  "date_created": "2026-03-02T18:01:35.799000Z",
  "date_modified": "2026-03-02T18:01:35.799000Z",
  "file_hash": "2b3915c978687447cbbf8812f48101faeaa3cecc71d4984670be09ef632419ee",
  "private": false,
  "record": {
    "abstract": "Human chromosome 21 is the only chromosome in human genome that exhibits\noscillation of (G+C)-content of cycle length of hundreds kilobases (500 kb near\nthe right telomere). We aim at establishing the existence of similar\nperiodicity in structure-related sequence features in order to relate this\n(G+C)% oscillation to other biological phenomena. The following quantities are\nshown to oscillate with the same 500kb periodicity in human chromosome 21:\nbinding energy calculated by two sets of dinucleotide-based thermodynamic\nparameters, AA/TT and AAA/TTT bi-/tri-nucleotide density, 5\u0027-TA-3\u0027 dinucleotide\ndensity, and signal for 10/11-base periodicity of AA/TT or AAA/TTT. These\nintrinsic quantities are related to structural features of the double helix of\nDNA molecules, such as base-pair binding, untwisting/unwinding, stiffness, and\na putative tendency for nucleosome formation.",
    "arxiv_id": "q-bio/0606016",
    "authors": [
      "Wentian Li",
      "Pedro Miramontes"
    ],
    "categories": [
      "q-bio.GN"
    ],
    "doi": "10.1103/PhysRevE.74.021912",
    "journal_ref": "Physical Review E, 74:021912 (2006)",
    "title": "Large-scale Oscillation of Structure-Related DNA Sequence Features in   Human Chromosome 21",
    "url": "https://arxiv.org/abs/q-bio/0606016"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "fbb514a1-e303-4914-9be5-f1ee697bc3ee",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}