dorsal/arxiv
View SchemaPhase synchronization in cerebral hemodynamics
| Authors | Miroslaw Latka, Malgorzata Turalska, Waldemar Kolodziej, Dariusz Latka, Brahm Goldstein, Bruce J. West |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0406026 |
| URL | https://arxiv.org/abs/q-bio/0406026 |
Abstract
A healthy human brain is perfused with blood flowing laminarly through cerebral vessels, providing brain tissue with substrates such as oxygen and glucose. Under normal conditions, cerebral blood flow is controlled by autoregulation as well as metabolic, chemical and neurogenic regulation. Physiological complexity of these mechanisms invariably leads to a question as to what are the relations between the statistical properties of arterial and intracranial pressure fluctuations. To shed new light on cerebral hemodynamics, we employ a complex continuous wavelet transform to determine the instantaneous phase difference between the arterial blood pressure (ABP) and intracranial pressure (ICP) in patients with traumatic brain injuries or spontaneous cerebral hemorrhage. For patients with mild to moderate injury, the phase difference slowly evolves in time. However, severe neurological injury with elevated ICP are herein associated with synchronization of arterial and intracranial pressure. We use Shannon entropy to quantify the stability of ABP-ICP phase difference and discuss the clinical applicability of such measure to assessment of cerebrovascular reactivity and autoregulation integrity.
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"abstract": "A healthy human brain is perfused with blood flowing laminarly through\ncerebral vessels, providing brain tissue with substrates such as oxygen and\nglucose. Under normal conditions, cerebral blood flow is controlled by\nautoregulation as well as metabolic, chemical and neurogenic regulation.\nPhysiological complexity of these mechanisms invariably leads to a question as\nto what are the relations between the statistical properties of arterial and\nintracranial pressure fluctuations. To shed new light on cerebral hemodynamics,\nwe employ a complex continuous wavelet transform to determine the instantaneous\nphase difference between the arterial blood pressure (ABP) and intracranial\npressure (ICP) in patients with traumatic brain injuries or spontaneous\ncerebral hemorrhage. For patients with mild to moderate injury, the phase\ndifference slowly evolves in time. However, severe neurological injury with\nelevated ICP are herein associated with synchronization of arterial and\nintracranial pressure. We use Shannon entropy to quantify the stability of\nABP-ICP phase difference and discuss the clinical applicability of such measure\nto assessment of cerebrovascular reactivity and autoregulation integrity.",
"arxiv_id": "q-bio/0406026",
"authors": [
"Miroslaw Latka",
"Malgorzata Turalska",
"Waldemar Kolodziej",
"Dariusz Latka",
"Brahm Goldstein",
"Bruce J. West"
],
"categories": [
"q-bio.OT"
],
"title": "Phase synchronization in cerebral hemodynamics",
"url": "https://arxiv.org/abs/q-bio/0406026"
},
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