dorsal/arxiv
View SchemaCooperative Gating and Spatial Organization of Membrane Proteins through Elastic Interactions
| Authors | Tristan Ursell, Kerwyn Huang, Eric Peterson, Rob Phillips |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0702031 |
| URL | https://arxiv.org/abs/q-bio/0702031 |
| DOI | 10.1371/journal.pcbi.0030081 |
Abstract
Biological membranes are elastic media in which the presence of a transmembrane protein leads to local bilayer deformation. The energetics of deformation allow two membrane proteins in close proximity to influence each other's equilibrium conformation via their local deformations, and spatially organize the proteins based on their geometry. We use the mechanosensitive channel of large conductance (MscL) as a case study to examine the implications of bilayer-mediated elastic interactions on protein conformational statistics and clustering. The deformations around MscL cost energy on the order of 10 kT and extend ~3nm from the protein edge, as such elastic forces induce cooperative gating and we propose experiments to measure these effects. Additionally, since elastic interactions are coupled to protein conformation, we find that conformational changes can severely alter the average separation between two proteins. This has important implications for how conformational changes organize membrane proteins into functional groups within membranes.
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"abstract": "Biological membranes are elastic media in which the presence of a\ntransmembrane protein leads to local bilayer deformation. The energetics of\ndeformation allow two membrane proteins in close proximity to influence each\nother\u0027s equilibrium conformation via their local deformations, and spatially\norganize the proteins based on their geometry. We use the mechanosensitive\nchannel of large conductance (MscL) as a case study to examine the implications\nof bilayer-mediated elastic interactions on protein conformational statistics\nand clustering. The deformations around MscL cost energy on the order of 10 kT\nand extend ~3nm from the protein edge, as such elastic forces induce\ncooperative gating and we propose experiments to measure these effects.\nAdditionally, since elastic interactions are coupled to protein conformation,\nwe find that conformational changes can severely alter the average separation\nbetween two proteins. This has important implications for how conformational\nchanges organize membrane proteins into functional groups within membranes.",
"arxiv_id": "q-bio/0702031",
"authors": [
"Tristan Ursell",
"Kerwyn Huang",
"Eric Peterson",
"Rob Phillips"
],
"categories": [
"q-bio.SC",
"q-bio.QM"
],
"doi": "10.1371/journal.pcbi.0030081",
"title": "Cooperative Gating and Spatial Organization of Membrane Proteins through Elastic Interactions",
"url": "https://arxiv.org/abs/q-bio/0702031"
},
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