{
  "annotation_id": "be6b9414-15fa-42a4-a2fe-85ca0dcec33d",
  "date_created": "2026-03-02T18:00:43.533000Z",
  "date_modified": "2026-03-02T18:00:43.533000Z",
  "file_hash": "790b05dd3ccb3c6fb518568d284b7b614c9237f6c7d94ffc0ec24b2812ae89a2",
  "private": false,
  "record": {
    "abstract": "A model of postphotodissociative monomolecular (geminate) recombination of\nheme proteins with small ligands (NO, O2 or CO) is represented. The\nnon-exponential decay with time for the probability to find a heme in unbound\nstate is interpreted in terms of diffusion-like migration of ligabs\nphysics/0212040 and between protein cavities. The temporal behavior for the\nprobability is obtained from numerical simulation and specified by two\nparameters: the time \\tau_{reb} of heme-ligand rebinding for the ligand\nlocalized inside the heme pocket and the time \\tau_{esc} of ligand escape from\nthe pocket. The model is applied in the analysis of available experimental data\nfor geminate reoxygenation of human hemoglobin HbA. Our simulation is in good\nagreement with the measurements. The analysis shows that the variation in pH of\nthe solution (6.0\u003cpH\u003c9.4) results in considerable changes for \\tau_{reb} from\n0.36 ns (at pH=8.5) up to 0.5 ns (pH=6.0) but effects slightly on the time\n\\tau_{esc} (\\tau_{esc} ~ 0.88 ns).",
    "arxiv_id": "physics/0212039",
    "authors": [
      "V. S. Starovoitov",
      "B. M. Dzhagarov"
    ],
    "categories": [
      "physics.bio-ph",
      "physics.chem-ph",
      "q-bio"
    ],
    "doi": "10.1016/S0301-0104(03)00248-9",
    "title": "A Diffusion-Based Approach to Geminate Recombination of Heme Proteins   with Small Ligands",
    "url": "https://arxiv.org/abs/physics/0212039"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "94f45977-1e4c-41b3-94d0-4b54cefaa127",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}