dorsal/arxiv
View SchemaCalculating event-triggered average synaptic conductances from the membrane potential
| Authors | Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal, Alain Destexhe |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0609030 |
| URL | https://arxiv.org/abs/q-bio/0609030 |
| Journal | Journal of Neurophysiology, 97: 2544--2552 (2007) |
Abstract
The optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally, such conductance time courses should be extracted from membrane potential (Vm) activity, but this is difficult because the nonlinear contribution of conductances to the Vm renders their estimation from the membrane equation extremely sensitive. We outline here a solution to this problem based on a discretization of the time axis. This procedure can extract the time course of excitatory and inhibitory conductances solely from the analysis of Vm activity. We test this method by calculating spike-triggered averages of synaptic conductances using numerical simulations of the integrate-and-fire model subject to colored conductance noise. The procedure was also tested successfully in biological cortical neurons using conductance noise injected with dynamic-clamp. This method should allow the extraction of synaptic conductances from Vm recordings in vivo.
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"abstract": "The optimal patterns of synaptic conductances for spike generation in central\nneurons is a subject of considerable interest. Ideally, such conductance time\ncourses should be extracted from membrane potential (Vm) activity, but this is\ndifficult because the nonlinear contribution of conductances to the Vm renders\ntheir estimation from the membrane equation extremely sensitive. We outline\nhere a solution to this problem based on a discretization of the time axis.\nThis procedure can extract the time course of excitatory and inhibitory\nconductances solely from the analysis of Vm activity. We test this method by\ncalculating spike-triggered averages of synaptic conductances using numerical\nsimulations of the integrate-and-fire model subject to colored conductance\nnoise. The procedure was also tested successfully in biological cortical\nneurons using conductance noise injected with dynamic-clamp. This method should\nallow the extraction of synaptic conductances from Vm recordings in vivo.",
"arxiv_id": "q-bio/0609030",
"authors": [
"Martin Pospischil",
"Zuzanna Piwkowska",
"Michelle Rudolph",
"Thierry Bal",
"Alain Destexhe"
],
"categories": [
"q-bio.NC"
],
"journal_ref": "Journal of Neurophysiology, 97: 2544--2552 (2007)",
"title": "Calculating event-triggered average synaptic conductances from the membrane potential",
"url": "https://arxiv.org/abs/q-bio/0609030"
},
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