dorsal/arxiv
View SchemaGraded and Binary Responses in Stochastic Gene Expression
| Authors | Rajesh Karmakar, Indrani Bose |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0411012 |
| URL | https://arxiv.org/abs/q-bio/0411012 |
| DOI | 10.1088/1478-3967/1/4/001 |
| Journal | Phys. Biol. 1 (2004) 197-204 |
Abstract
Recently, several theoretical and experimental studies have been undertaken to probe the effect of stochasticity on gene expression (GE). In experiments, the GE response to an inducing signal in a cell, measured by the amount of mRNAs/proteins synthesized, is found to be either graded or binary. The latter type of response gives rise to a bimodal distribution in protein levels in an ensemble of cells. One possible origin of binary response is cellular bistability achieved through positive feedback or autoregulation. In this paper, we study a simple, stochastic model of GE and show that the origin of binary response lies exclusively in stochasticity. The transitions between the active and inactive states of the gene are random in nature. Graded and binary responses occur in the model depending on the relative stability of the activated and deactivated gene states with respect to that of mRNAs/proteins.The theoretical results on binary response provide a good description of the ``all-or-none'' phenomenon observed in an eukaryotic system.
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"abstract": "Recently, several theoretical and experimental studies have been undertaken\nto probe the effect of stochasticity on gene expression (GE). In experiments,\nthe GE response to an inducing signal in a cell, measured by the amount of\nmRNAs/proteins synthesized, is found to be either graded or binary. The latter\ntype of response gives rise to a bimodal distribution in protein levels in an\nensemble of cells. One possible origin of binary response is cellular\nbistability achieved through positive feedback or autoregulation. In this\npaper, we study a simple, stochastic model of GE and show that the origin of\nbinary response lies exclusively in stochasticity. The transitions between the\nactive and inactive states of the gene are random in nature. Graded and binary\nresponses occur in the model depending on the relative stability of the\nactivated and deactivated gene states with respect to that of\nmRNAs/proteins.The theoretical results on binary response provide a good\ndescription of the ``all-or-none\u0027\u0027 phenomenon observed in an eukaryotic system.",
"arxiv_id": "q-bio/0411012",
"authors": [
"Rajesh Karmakar",
"Indrani Bose"
],
"categories": [
"q-bio.OT",
"cond-mat.stat-mech"
],
"doi": "10.1088/1478-3967/1/4/001",
"journal_ref": "Phys. Biol. 1 (2004) 197-204",
"title": "Graded and Binary Responses in Stochastic Gene Expression",
"url": "https://arxiv.org/abs/q-bio/0411012"
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