dorsal/arxiv
View SchemaAmplified biochemical oscillations in cellular systems
| Authors | A. J. McKane, J. D. Nagy, T. J. Newman, M. O. Stefanini |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0604001 |
| URL | https://arxiv.org/abs/q-bio/0604001 |
| DOI | 10.1007/s10955-006-9221-9 |
Abstract
We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations, fail to exhibit oscillations for any values of rate constants. The mechanism relies on amplification of the underlying stochasticity of reaction kinetics within a narrow window of frequencies. This amplification allows fluctuations to beat the central limit theorem, having a dominant effect even though the number of molecules in the system is relatively large. The mechanism is quantitatively studied within simple models of self-regulatory gene expression, and glycolytic oscillations.
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"abstract": "We describe a mechanism for pronounced biochemical oscillations, relevant to\nmicroscopic systems, such as the intracellular environment. This mechanism\noperates for reaction schemes which, when modeled using deterministic rate\nequations, fail to exhibit oscillations for any values of rate constants. The\nmechanism relies on amplification of the underlying stochasticity of reaction\nkinetics within a narrow window of frequencies. This amplification allows\nfluctuations to beat the central limit theorem, having a dominant effect even\nthough the number of molecules in the system is relatively large. The mechanism\nis quantitatively studied within simple models of self-regulatory gene\nexpression, and glycolytic oscillations.",
"arxiv_id": "q-bio/0604001",
"authors": [
"A. J. McKane",
"J. D. Nagy",
"T. J. Newman",
"M. O. Stefanini"
],
"categories": [
"q-bio.CB",
"cond-mat.stat-mech",
"q-bio.BM"
],
"doi": "10.1007/s10955-006-9221-9",
"title": "Amplified biochemical oscillations in cellular systems",
"url": "https://arxiv.org/abs/q-bio/0604001"
},
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