{
  "annotation_id": "ba83d0a7-07f2-40a4-8213-3697be6d4555",
  "date_created": "2026-03-02T18:01:35.299000Z",
  "date_modified": "2026-03-02T18:01:35.299000Z",
  "file_hash": "cfe6413fe7e3cf109cc4a691c97eda901e0a080773c7753ff1dfd1169c3cc7db",
  "private": false,
  "record": {
    "abstract": "We describe a mechanism for pronounced biochemical oscillations, relevant to\nmicroscopic systems, such as the intracellular environment. This mechanism\noperates for reaction schemes which, when modeled using deterministic rate\nequations, fail to exhibit oscillations for any values of rate constants. The\nmechanism relies on amplification of the underlying stochasticity of reaction\nkinetics within a narrow window of frequencies. This amplification allows\nfluctuations to beat the central limit theorem, having a dominant effect even\nthough the number of molecules in the system is relatively large. The mechanism\nis quantitatively studied within simple models of self-regulatory gene\nexpression, and glycolytic oscillations.",
    "arxiv_id": "q-bio/0604001",
    "authors": [
      "A. J. McKane",
      "J. D. Nagy",
      "T. J. Newman",
      "M. O. Stefanini"
    ],
    "categories": [
      "q-bio.CB",
      "cond-mat.stat-mech",
      "q-bio.BM"
    ],
    "doi": "10.1007/s10955-006-9221-9",
    "title": "Amplified biochemical oscillations in cellular systems",
    "url": "https://arxiv.org/abs/q-bio/0604001"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a8bd1c24-90b3-4c4a-af23-6284f580cfde",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}