{
  "annotation_id": "b8f89ac3-c0bd-4264-8b32-6656709feb12",
  "date_created": "2026-03-02T18:01:31.153000Z",
  "date_modified": "2026-03-02T18:01:31.153000Z",
  "file_hash": "ae03b7ced7a780a01e642862a7649434ce0c20cc9e7325bd749c689ef6948f10",
  "private": false,
  "record": {
    "abstract": "We study the mechanism underlying the attraction between nucleosomes, the\nfundamental packaging units of DNA inside the chromatin complex. We introduce a\nsimple model of the nucleosome, the eight-tail colloid, consisting of a charged\nsphere with eight oppositely charged, flexible, grafted chains that represent\nthe terminal histone tails. We demonstrate that our complexes are attracted via\nthe formation of chain bridges and that this attraction can be tuned by\nchanging the fraction of charged monomers on the tails. This suggests a\nphysical mechanism of chromatin compaction where the degree of DNA condensation\ncan be controlled via biochemical means, namely the acetylation and\ndeacetylation of lysines in the histone tails.",
    "arxiv_id": "q-bio/0503007",
    "authors": [
      "Frank Muehlbacher",
      "Christian Holm",
      "Helmut Schiessel"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "doi": "10.1209/epl/i2005-10351-4",
    "title": "Controlled DNA compaction within chromatin: the tail-bridging effect",
    "url": "https://arxiv.org/abs/q-bio/0503007"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "5c81f349-c4de-47cb-bd3e-ec747b931b08",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}