{
  "annotation_id": "b6f0ed8b-0d24-4f76-8f0a-73b42fa72233",
  "date_created": "2026-03-02T18:01:34.901000Z",
  "date_modified": "2026-03-02T18:01:34.901000Z",
  "file_hash": "995df044724390fe38952e582be1fde99604c8f1686628208002c6e2fac9d977",
  "private": false,
  "record": {
    "abstract": "We study by simulation the effect of the diffusive motion of repressor\nmolecules on the noise in mRNA and protein levels in the case of a repressed\ngene. We find that spatial fluctuations due to diffusion can drastically\nenhance the noise in gene expression. For a fixed repressor strength, the noise\ndue to diffusion can be minimized by increasing the number of repressors or by\ndecreasing the rate of the open complex formation. We also show that the effect\nof spatial fluctuations can be well described by a two-step kinetic scheme,\nwhere formation of an encounter complex by diffusion and the subsequent\nassociation reaction are treated separately. Our results also emphasize that\npower spectra are a highly useful tool for studying the propagation of noise\nthrough the different stages of gene expression.",
    "arxiv_id": "q-bio/0604005",
    "authors": [
      "Jeroen S. van Zon",
      "Marco J. Morelli",
      "Sorin Tanase-Nicola",
      "Pieter Rein ten Wolde"
    ],
    "categories": [
      "q-bio.MN"
    ],
    "title": "Diffusion of transcription factors can drastically enhance the noise in   gene expression",
    "url": "https://arxiv.org/abs/q-bio/0604005"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "704a7fb3-8242-47b5-b38d-4e720368def9",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}