dorsal/arxiv
View SchemaPersistence Length Changes Dramatically as RNA Folds
| Authors | G. Caliskan, C. Hyeon, U. Perez-Salas, R. M. Briber, S. A. Woodson, D. Thirumalai |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511027 |
| URL | https://arxiv.org/abs/q-bio/0511027 |
| DOI | 10.1103/PhysRevLett.95.268303 |
| Journal | Phys. Rev. Lett 95, 268303 (2005) |
Abstract
We determine the persistence length, $l_p$, for a bacterial group I ribozyme as a function of concentration of monovalent and divalent cations by fitting the distance distribution functions $P(r)$ obtained from small angle X-ray scattering intensity data to the asymptotic form of the calculated $P_{WLC}(r)$ for a worm-like chain (WLC). The $l_p$ values change dramatically over a narrow range of \Mg concentration from $\sim$21 \AA in the unfolded state (\textbf{U}) to $\sim$10 \AA in the compact ($\mathrm{I_C}$) and native states. Variations in $l_p$ with increasing \Na concentration are more gradual. In accord with the predictions of polyelectrolyte theory we find $l_p \propto 1/ \kappa^2$ where $\kappa$ is the inverse Debye-screening length.
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"abstract": "We determine the persistence length, $l_p$, for a bacterial group I ribozyme\nas a function of concentration of monovalent and divalent cations by fitting\nthe distance distribution functions $P(r)$ obtained from small angle X-ray\nscattering intensity data to the asymptotic form of the calculated $P_{WLC}(r)$\nfor a worm-like chain (WLC). The $l_p$ values change dramatically over a narrow\nrange of \\Mg concentration from $\\sim$21 \\AA in the unfolded state (\\textbf{U})\nto $\\sim$10 \\AA in the compact ($\\mathrm{I_C}$) and native states. Variations\nin $l_p$ with increasing \\Na concentration are more gradual. In accord with the\npredictions of polyelectrolyte theory we find $l_p \\propto 1/ \\kappa^2$ where\n$\\kappa$ is the inverse Debye-screening length.",
"arxiv_id": "q-bio/0511027",
"authors": [
"G. Caliskan",
"C. Hyeon",
"U. Perez-Salas",
"R. M. Briber",
"S. A. Woodson",
"D. Thirumalai"
],
"categories": [
"q-bio.BM",
"cond-mat.soft",
"q-bio.QM"
],
"doi": "10.1103/PhysRevLett.95.268303",
"journal_ref": "Phys. Rev. Lett 95, 268303 (2005)",
"title": "Persistence Length Changes Dramatically as RNA Folds",
"url": "https://arxiv.org/abs/q-bio/0511027"
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