dorsal/arxiv
View SchemaKinesin as an electrostatic machine
| Authors | A. Ciudad, J. M. Sancho, G. P. Tsironis |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0610045 |
| URL | https://arxiv.org/abs/q-bio/0610045 |
| DOI | 10.1007/s10867-006-9028-6 |
Abstract
Kinesin and related motor proteins utilize ATP fuel to propel themselves along the external surface of microtubules in a processive and directional fashion. We show that the observed step-like motion is possible through time varying charge distributions furnished by the ATP hydrolysis circle while the static charge configuration on the microtuble provides the guide for motion. Thus, while the chemical hydrolysis energy induces appropriate local conformational changes, the motor translational energy is fundamentally electrostatic. Numerical simulations of the mechanical equations of motion show that processivity and directionality are direct consequences of the ATP-dependent electrostatic interaction between the different charge distributions of kinesin and microtubule.
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"abstract": "Kinesin and related motor proteins utilize ATP fuel to propel themselves\nalong the external surface of microtubules in a processive and directional\nfashion. We show that the observed step-like motion is possible through time\nvarying charge distributions furnished by the ATP hydrolysis circle while the\nstatic charge configuration on the microtuble provides the guide for motion.\nThus, while the chemical hydrolysis energy induces appropriate local\nconformational changes, the motor translational energy is fundamentally\nelectrostatic. Numerical simulations of the mechanical equations of motion show\nthat processivity and directionality are direct consequences of the\nATP-dependent electrostatic interaction between the different charge\ndistributions of kinesin and microtubule.",
"arxiv_id": "q-bio/0610045",
"authors": [
"A. Ciudad",
"J. M. Sancho",
"G. P. Tsironis"
],
"categories": [
"q-bio.BM",
"cond-mat.stat-mech",
"physics.bio-ph"
],
"doi": "10.1007/s10867-006-9028-6",
"title": "Kinesin as an electrostatic machine",
"url": "https://arxiv.org/abs/q-bio/0610045"
},
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