dorsal/arxiv
View SchemaUnbalanced synaptic inhibition can create intensity-tuned auditory cortex neurons
| Authors | Andrew Y. Y. Tan, Craig A. Atencio, Daniel B. Polley, Michael M. Merzenich, Christoph E. Schreiner |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0607036 |
| URL | https://arxiv.org/abs/q-bio/0607036 |
| DOI | 10.1016/j.neuroscience.2007.01.019 |
| Journal | Neuroscience 146: 449-462 (2007) |
Abstract
Intensity-tuned auditory cortex neurons may be formed by intensity-tuned synaptic excitation. Synaptic inhibition has also been shown to enhance, and possibly even create intensity-tuned neurons. Here we show, using in vivo whole cell recordings in pentobarbital-anesthetized rats, that some intensity-tuned neurons are indeed created solely through disproportionally large inhibition at high intensities, without any intensity-tuned excitation. Since inhibition is essentially cortical in origin, these neurons provide examples of auditory feature-selectivity arising de novo at the cortex.
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"abstract": "Intensity-tuned auditory cortex neurons may be formed by intensity-tuned\nsynaptic excitation. Synaptic inhibition has also been shown to enhance, and\npossibly even create intensity-tuned neurons. Here we show, using in vivo whole\ncell recordings in pentobarbital-anesthetized rats, that some intensity-tuned\nneurons are indeed created solely through disproportionally large inhibition at\nhigh intensities, without any intensity-tuned excitation. Since inhibition is\nessentially cortical in origin, these neurons provide examples of auditory\nfeature-selectivity arising de novo at the cortex.",
"arxiv_id": "q-bio/0607036",
"authors": [
"Andrew Y. Y. Tan",
"Craig A. Atencio",
"Daniel B. Polley",
"Michael M. Merzenich",
"Christoph E. Schreiner"
],
"categories": [
"q-bio.NC"
],
"doi": "10.1016/j.neuroscience.2007.01.019",
"journal_ref": "Neuroscience 146: 449-462 (2007)",
"title": "Unbalanced synaptic inhibition can create intensity-tuned auditory cortex neurons",
"url": "https://arxiv.org/abs/q-bio/0607036"
},
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