{
  "annotation_id": "b0a0f8a7-902d-428e-8c39-b5461969cb31",
  "date_created": "2026-03-02T18:01:32.172000Z",
  "date_modified": "2026-03-02T18:01:32.172000Z",
  "file_hash": "69b9b47f443202d427f114cfceccaa52984aa25d469e6dfa4633e11a64c12b99",
  "private": false,
  "record": {
    "abstract": "In eukaryote nucleosome, DNA wraps around a histone octamer in a left-handed\nway. We study the process of chirality formation of nucleosome with Brownian\ndynamics simulation. We model the histone octamer with a quantitatively\nadjustable chirality: left-handed, right-handed or non-chiral, and simulate the\ndynamical wrapping process of a DNA molecule on it. We find that the chirality\nof a nucleosome formed is strongly dependent on that of the histone octamer,\nand different chiralities of the histone octamer induce its different rotation\ndirections in the wrapping process of DNA. In addition, a very weak chirality\nof the histone octamer is quite enough for sustaining the correct chirality of\nthe nucleosome formed. We also show that the chirality of a nucleosome may be\nbroken at elevated temperature.",
    "arxiv_id": "q-bio/0505034",
    "authors": [
      "Wei Li",
      "Shuo-Xing Dou",
      "Peng-Ye Wang"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "journal_ref": "Journal of Theoretical Biology 235 (2005) 365-372",
    "title": "The histone octamer influences the wrapping direction of DNA on it:   Brownian dynamics simulation of the nucleosome chirality",
    "url": "https://arxiv.org/abs/q-bio/0505034"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "6ba315b1-6a1b-4f1f-ae0e-fcaeea60c8f9",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}