dorsal/arxiv
View SchemaKinetics of viral self-assembly: the role of ss RNA antenna
| Authors | Tao Hu, B. I. Shklovskii |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611066 |
| URL | https://arxiv.org/abs/q-bio/0611066 |
| DOI | 10.1103/PhysRevE.75.051901 |
| Journal | Phys. Rev. E 75, 051901 (2007) |
Abstract
A big class of viruses self-assemble from a large number of identical capsid proteins with long flexible N-terminal tails and ss RNA. We study the role of the strong Coulomb interaction of positive N-terminal tails with ss RNA in the kinetics of the in vitro virus self-assembly. Capsid proteins stick to unassembled chain of ss RNA (which we call "antenna") and slide on it towards the assembly site. We show that at excess of capsid proteins such one-dimensional diffusion accelerates self-assembly more than ten times. On the other hand at excess of ss RNA, antenna slows self-assembly down. Several experiments are proposed to verify the role of ss RNA antenna.
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"abstract": "A big class of viruses self-assemble from a large number of identical capsid\nproteins with long flexible N-terminal tails and ss RNA. We study the role of\nthe strong Coulomb interaction of positive N-terminal tails with ss RNA in the\nkinetics of the in vitro virus self-assembly. Capsid proteins stick to\nunassembled chain of ss RNA (which we call \"antenna\") and slide on it towards\nthe assembly site. We show that at excess of capsid proteins such\none-dimensional diffusion accelerates self-assembly more than ten times. On the\nother hand at excess of ss RNA, antenna slows self-assembly down. Several\nexperiments are proposed to verify the role of ss RNA antenna.",
"arxiv_id": "q-bio/0611066",
"authors": [
"Tao Hu",
"B. I. Shklovskii"
],
"categories": [
"q-bio.BM",
"cond-mat.soft"
],
"doi": "10.1103/PhysRevE.75.051901",
"journal_ref": "Phys. Rev. E 75, 051901 (2007)",
"title": "Kinetics of viral self-assembly: the role of ss RNA antenna",
"url": "https://arxiv.org/abs/q-bio/0611066"
},
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