{
  "annotation_id": "aede6d6b-d31c-4aba-8e8e-d944ba776834",
  "date_created": "2026-03-02T18:01:34.731000Z",
  "date_modified": "2026-03-02T18:01:34.731000Z",
  "file_hash": "88d7ee7d59f33162474caf756cd6823d37fe19ff49bb3222f4576665497f457c",
  "private": false,
  "record": {
    "abstract": "Owing to the complexity of higher eukaryotic cells, a complete proteome is\nlikely to be very difficult to achieve. However, advantage can be taken of the\ncell compartmentalization to build organelle proteomes, which can moreover be\nviewed as specialized tools to study specifically the biology and \"physiology\"\nof the target organelle. Within this frame, we report here the construction of\nthe human mitochondrial proteome, using placenta as the source tissue. Protein\nidentification was carried out mainly by peptide mass fingerprinting. The\noptimization steps in two-dimensional electrophoresis needed for proteome\nresearch are discussed. However, the relative paucity of data concerning\nmitochondrial proteins is still the major limiting factor in building the\ncorresponding proteome, which should be a useful tool for researchers working\non human mitochondria and their deficiencies.",
    "arxiv_id": "q-bio/0611075",
    "authors": [
      "Pierre Lescuyer",
      "Jean-Marc Strub",
      "Sylvie Luche",
      "H\u00e9l\u00e8ne Diemer",
      "Pascal Martinez",
      "Alain Van Dorsselaer",
      "Jo\u00ebl Lunardi",
      "Thierry Rabilloud"
    ],
    "categories": [
      "q-bio.GN"
    ],
    "doi": "10.1002/pmic.200390024",
    "journal_ref": "Proteomics 3 (02/2003) 157-67",
    "title": "Progress in the definition of a reference human mitochondrial proteome",
    "url": "https://arxiv.org/abs/q-bio/0611075"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "5088065f-3c3b-4009-85a1-c9055a20aabe",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}