{
  "annotation_id": "ad25127f-51ae-4c7a-a150-2c2e2a972633",
  "date_created": "2026-03-02T18:01:00.413000Z",
  "date_modified": "2026-03-02T18:01:00.413000Z",
  "file_hash": "062426716572a6d03a03503b28d2278efcb42f46702f5cac244469a4a21e3da1",
  "private": false,
  "record": {
    "abstract": "Multi-strain diseases are diseases that consist of several strains, or\nserotypes. The serotypes may interact by antibody-dependent enhancement (ADE),\nin which infection with a single serotype is asymptomatic, but infection with a\nsecond serotype leads to serious illness accompanied by greater infectivity. It\nhas been observed from serotype data of dengue hemorrhagic fever that outbreaks\nof the four serotypes occur asynchronously. Both autonomous and seasonally\ndriven outbreaks were studied in a model containing ADE. For sufficiently small\nADE, the number of infectives of each serotype synchronizes, with outbreaks\noccurring in phase. When the ADE increases past a threshold, the system becomes\nchaotic, and infectives of each serotype desynchronize. However, certain\ngroupings of the primary and second ary infectives remain synchronized even in\nthe chaotic regime.",
    "arxiv_id": "physics/0510005",
    "authors": [
      "Ira B. Schwartz",
      "Leah B. Shaw",
      "Derek A. T. Cummings",
      "Lora Billings",
      "Marie McCrary",
      "Donald S. Burke"
    ],
    "categories": [
      "physics.bio-ph"
    ],
    "doi": "10.1103/PhysRevE.72.066201",
    "title": "Chaotic desynchronization of multi-strain diseases",
    "url": "https://arxiv.org/abs/physics/0510005"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "272cb06b-2f4f-4c12-aa37-049bb5b5d5e3",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}