{
  "annotation_id": "acdbddfb-68c1-404f-b7de-b9bd2060d7b6",
  "date_created": "2026-03-02T18:01:35.333000Z",
  "date_modified": "2026-03-02T18:01:35.333000Z",
  "file_hash": "88716102b3b9a6a76f8cb39881b16bbd631d6fd6a34ec60d7598eab7b1ad016c",
  "private": false,
  "record": {
    "abstract": "Excitability is an attribute of life, and is a driving force in the descent\nof complexity. Cellular electrical activity as realized by membrane proteins\nthat act as either channels or transporters is the basis of excitability.\nElectrical signaling is mediated by a wave of action potentials, which consist\nof synchronous redistribution of ionic gradients down ion channels. Ion\nchannels select for the passage of a particular ion species. Potassium ion\nchannels are gated by a variety of stimuli, including membrane voltage. Sodium\nand calcium channels are gated only by membrane voltage, suggesting the\nconservative argument that voltage-gated potassium channels are the founding\nmembers of the voltage-gated ion channel superfamily. The principal focus of\nthis work is the investigation of the complement of potassium ion channels in\nour genome and its generalizabilty. An array of issues relevant to excitability\nis addressed, and a range of engagement in questions regarding the unity of\nlife is proffered.",
    "arxiv_id": "q-bio/0609023",
    "authors": [
      "Ashok Palaniappan",
      "Eric Jakobsson"
    ],
    "categories": [
      "q-bio.BM",
      "q-bio.CB",
      "q-bio.GN",
      "q-bio.PE"
    ],
    "license": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
    "title": "Evolutionary Analysis of Biological Excitability",
    "url": "https://arxiv.org/abs/q-bio/0609023"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "33dcc060-60d3-485e-a100-476697dbc439",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}