dorsal/arxiv
View SchemaCorrectly validating results from single molecule data: the case of stretched exponential decay in the catalytic activity of single lipase B molecules
| Authors | Ophir Flomenbom, Johan Hofkens, Kelly Velonia, Frans C. de Schryver, Alan E. Rowan, Roeland J. M. Nolte, Joseph Klafter, Robert J. Silbey |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0702045 |
| URL | https://arxiv.org/abs/q-bio/0702045 |
| DOI | 10.1016/j.cplett.2006.10.060 |
| Journal | Chem. Phys. Lett. 432, 371-374 (2006) |
Abstract
The question of how to validate and interpret correctly the waiting time probability density functions (WT-PDFs) from single molecule data is addressed. It is shown by simulation that when a stretched exponential WT-PDF, with a stretched exponent alfa and a time scale parameter tau, generates the off periods of a two-state trajectory, a reliable recovery of the input WT-PDF from the trajectory is obtained even when the bin size used to define the trajectory, dt, is much larger than the parameter tau. This holds true as long as the first moment of the WT-PDF is much larger than dt. Our results validate the results in an earlier study of the activity of single Lipase B molecules and disprove recent related critique.
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"abstract": "The question of how to validate and interpret correctly the waiting time\nprobability density functions (WT-PDFs) from single molecule data is addressed.\nIt is shown by simulation that when a stretched exponential WT-PDF, with a\nstretched exponent alfa and a time scale parameter tau, generates the off\nperiods of a two-state trajectory, a reliable recovery of the input WT-PDF from\nthe trajectory is obtained even when the bin size used to define the\ntrajectory, dt, is much larger than the parameter tau. This holds true as long\nas the first moment of the WT-PDF is much larger than dt. Our results validate\nthe results in an earlier study of the activity of single Lipase B molecules\nand disprove recent related critique.",
"arxiv_id": "q-bio/0702045",
"authors": [
"Ophir Flomenbom",
"Johan Hofkens",
"Kelly Velonia",
"Frans C. de Schryver",
"Alan E. Rowan",
"Roeland J. M. Nolte",
"Joseph Klafter",
"Robert J. Silbey"
],
"categories": [
"q-bio.SC",
"cond-mat.soft",
"q-bio.BM"
],
"doi": "10.1016/j.cplett.2006.10.060",
"journal_ref": "Chem. Phys. Lett. 432, 371-374 (2006)",
"title": "Correctly validating results from single molecule data: the case of stretched exponential decay in the catalytic activity of single lipase B molecules",
"url": "https://arxiv.org/abs/q-bio/0702045"
},
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