dorsal/arxiv
View SchemaA stochastic model of Min oscillations in Escherichia coli and Min protein segregation during cell division
| Authors | Filipe Tostevin, Martin Howard |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511049 |
| URL | https://arxiv.org/abs/q-bio/0511049 |
| DOI | 10.1088/1478-3975/3/1/001 |
| Journal | Phys. Biol. 3 (2006) 1-12 |
Abstract
The Min system in Escherichia coli directs division to the centre of the cell through pole-to-pole oscillations of the MinCDE proteins. We present a one dimensional stochastic model of these oscillations which incorporates membrane polymerisation of MinD into linear chains. This model reproduces much of the observed phenomenology of the Min system, including pole-to-pole oscillations of the Min proteins. We then apply this model to investigate the Min system during cell division. Oscillations continue initially unaffected by the closing septum, before cutting off rapidly. The fractions of Min proteins in the daughter cells vary widely, from 50%-50% up to 85%-15% of the total from the parent cell, suggesting that there may be another mechanism for regulating these levels in vivo.
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"abstract": "The Min system in Escherichia coli directs division to the centre of the cell\nthrough pole-to-pole oscillations of the MinCDE proteins. We present a one\ndimensional stochastic model of these oscillations which incorporates membrane\npolymerisation of MinD into linear chains. This model reproduces much of the\nobserved phenomenology of the Min system, including pole-to-pole oscillations\nof the Min proteins. We then apply this model to investigate the Min system\nduring cell division. Oscillations continue initially unaffected by the closing\nseptum, before cutting off rapidly. The fractions of Min proteins in the\ndaughter cells vary widely, from 50%-50% up to 85%-15% of the total from the\nparent cell, suggesting that there may be another mechanism for regulating\nthese levels in vivo.",
"arxiv_id": "q-bio/0511049",
"authors": [
"Filipe Tostevin",
"Martin Howard"
],
"categories": [
"q-bio.SC",
"cond-mat.stat-mech"
],
"doi": "10.1088/1478-3975/3/1/001",
"journal_ref": "Phys. Biol. 3 (2006) 1-12",
"title": "A stochastic model of Min oscillations in Escherichia coli and Min protein segregation during cell division",
"url": "https://arxiv.org/abs/q-bio/0511049"
},
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