dorsal/arxiv
View SchemaModulation of the reaction rate of regulating protein induces large morphological and motional change of amoebic cell
| Authors | Shin I. Nishimura, Masaki Sasai |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0610005 |
| URL | https://arxiv.org/abs/q-bio/0610005 |
Abstract
Morphologies of moving amoebae are categorized into two types. One is the ``neutrophil'' type in which the long axis of cell roughly coincides with its moving direction. This type of cell extends a leading edge at the front and retracts a narrow tail at the rear, whose shape has been often drawn as a typical amoeba in textbooks. The other one is the ``keratocyte'' type with widespread lamellipodia along the front side arc. Short axis of cell in this type roughly coincides with its moving direction. In order to understand what kind of molecular feature causes conversion between two types of morphologies, and how two typical morphologies are maintained, a mathematical model of amoebic cells is developed. This model describes movement of cell and intracellular reactions of activator, inhibitor and actin filaments in a unified way. It is found that the producing rate of activator is a key factor of conversion between two types. This model also explains the observed data that the keratocye type cells tend to rapidly move along a straight line. The neutrophil type cells move along a straight line when the moving velocity is small, but they show fluctuated motions deviating from a line when they move as fast as the keratocye type cells. Efficient energy consumption in the neutrophil type cells is predicted.
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"abstract": "Morphologies of moving amoebae are categorized into two types. One is the\n``neutrophil\u0027\u0027 type in which the long axis of cell roughly coincides with its\nmoving direction. This type of cell extends a leading edge at the front and\nretracts a narrow tail at the rear, whose shape has been often drawn as a\ntypical amoeba in textbooks. The other one is the ``keratocyte\u0027\u0027 type with\nwidespread lamellipodia along the front side arc. Short axis of cell in this\ntype roughly coincides with its moving direction. In order to understand what\nkind of molecular feature causes conversion between two types of morphologies,\nand how two typical morphologies are maintained, a mathematical model of\namoebic cells is developed. This model describes movement of cell and\nintracellular reactions of activator, inhibitor and actin filaments in a\nunified way. It is found that the producing rate of activator is a key factor\nof conversion between two types. This model also explains the observed data\nthat the keratocye type cells tend to rapidly move along a straight line. The\nneutrophil type cells move along a straight line when the moving velocity is\nsmall, but they show fluctuated motions deviating from a line when they move as\nfast as the keratocye type cells. Efficient energy consumption in the\nneutrophil type cells is predicted.",
"arxiv_id": "q-bio/0610005",
"authors": [
"Shin I. Nishimura",
"Masaki Sasai"
],
"categories": [
"q-bio.CB"
],
"title": "Modulation of the reaction rate of regulating protein induces large morphological and motional change of amoebic cell",
"url": "https://arxiv.org/abs/q-bio/0610005"
},
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