dorsal/arxiv
View SchemaAlternative Splicing and Genomic Stability
| Authors | Kevin Cahill |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0403039 |
| URL | https://arxiv.org/abs/q-bio/0403039 |
| DOI | 10.1088/1478-3967/1/2/C01 |
| Journal | Physical Biology, volume 1, issue 2, pages C1 - C4, 2004 |
Abstract
Alternative splicing allows an organism to make different proteins in different cells at different times, all from the same gene. In a cell that uses alternative splicing, the total length of all the exons is much shorter than in a cell that encodes the same set of proteins without alternative splicing. This economical use of exons makes genes more stable during reproduction and development because a genome with a shorter exon length is more resistant to harmful mutations. Genomic stability may be the reason why higher vertebrates splice alternatively. For a broad class of alternatively spliced genes, a formula is given for the increase in their stability.
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"abstract": "Alternative splicing allows an organism to make different proteins in\ndifferent cells at different times, all from the same gene. In a cell that uses\nalternative splicing, the total length of all the exons is much shorter than in\na cell that encodes the same set of proteins without alternative splicing. This\neconomical use of exons makes genes more stable during reproduction and\ndevelopment because a genome with a shorter exon length is more resistant to\nharmful mutations. Genomic stability may be the reason why higher vertebrates\nsplice alternatively. For a broad class of alternatively spliced genes, a\nformula is given for the increase in their stability.",
"arxiv_id": "q-bio/0403039",
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"doi": "10.1088/1478-3967/1/2/C01",
"journal_ref": "Physical Biology, volume 1, issue 2, pages C1 - C4, 2004",
"title": "Alternative Splicing and Genomic Stability",
"url": "https://arxiv.org/abs/q-bio/0403039"
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