{
  "annotation_id": "a5d5e292-5061-41fe-bb8d-e9e2691e71dc",
  "date_created": "2026-03-02T18:00:46.167000Z",
  "date_modified": "2026-03-02T18:00:46.167000Z",
  "file_hash": "d187889124fa19f45861246dd7a9d3e4476aaf315ca114f5fa407dcd0286e4e9",
  "private": false,
  "record": {
    "abstract": "We studied the adsorption of a charged protein onto an oppositely charged\nmembrane, composed of mobile phospholipids of differing valence, using a\nstatistical-thermodynamical approach. A two-block model was employed, one block\ncorresponding to the protein-affected region on the membrane, referred to as\nthe adsorption domain, and the other to the unaffected remainder of the\nmembrane. We calculated the protein-induced lipid rearrangement in the\nadsorption domain as arising from the interplay between the electrostatic\ninteractions in the system and the mixing entropy of the lipids. Equating the\nelectrochemical potentials of the lipids in the two blocks yields an expression\nfor the relations among the various lipid fractions in the adsorption domain,\nindicating a sensitive dependence of lipid fraction on valence. This expression\nis a result of the two-block picture but does not depend on further details of\nthe protein-membrane interaction. We subsequently calculated the lipid\nfractions themselves using the Poisson-Boltzmann theory. We examined the\ndependence of lipid enrichment, i.e., the ratio between the lipid fractions\ninside and outside the adsorption domain, on various parameters such as ionic\nstrength and lipid valence. Maximum enrichment was found for lipid valence of\nabout (-3) to (-4) in physiological conditions. Our results are in qualitative\nagreement with recent experimental studies on the interactions between peptides\nhaving a domain of basic residues and membranes containing a small fraction of\nthe polyvalent phosphatidylinositol 4,5-bisphosphate (PIP2). This study\nprovides theoretical support for the suggestion that proteins adsorbed onto\nmembranes through a cluster of basic residues may sequester PIP2 and other\npolyvalent lipids.",
    "arxiv_id": "physics/0308085",
    "authors": [
      "Emir Haleva",
      "Nir Ben-Tal",
      "Haim Diamant"
    ],
    "categories": [
      "physics.bio-ph",
      "cond-mat.soft",
      "q-bio.SC"
    ],
    "doi": "10.1016/S0006-3495(04)74276-9",
    "journal_ref": "Biophys. J. 86, 2165 (2004)",
    "title": "Increased Concentration of Polyvalent Phospholipids in the Adsorption   Domain of a Charged Protein",
    "url": "https://arxiv.org/abs/physics/0308085"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "dfd61682-e677-4aa4-bd24-b454d3396421",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}