dorsal/arxiv
View SchemaDynamic Studies of Scaffold-dependent Mating Pathway in Yeast
| Authors | Danying Shao, Wen Zheng, Wenjun Qiu, Qi Ouyang, Chao Tang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0609015 |
| URL | https://arxiv.org/abs/q-bio/0609015 |
| DOI | 10.1529/biophysj.106.081661 |
Abstract
The mating pathway in \emph{Saccharomyces cerevisiae} is one of the best understood signal transduction pathways in eukaryotes. It transmits the mating signal from plasma membrane into the nucleus through the G-protein coupled receptor and the mitogen-activated protein kinase (MAPK) cascade. According to the current understandings of the mating pathway, we construct a system of ordinary differential equations to describe the process. Our model is consistent with a wide range of experiments, indicating that it captures some main characteristics of the signal transduction along the pathway. Investigation with the model reveals that the shuttling of the scaffold protein and the dephosphorylation of kinases involved in the MAPK cascade cooperate to regulate the response upon pheromone induction and to help preserving the fidelity of the mating signaling. We explored factors affecting the dose-response curves of this pathway and found that both negative feedback and concentrations of the proteins involved in the MAPK cascade play crucial role. Contrary to some other MAPK systems where signaling sensitivity is being amplified successively along the cascade, here the mating signal is transmitted through the cascade in an almost linear fashion.
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"abstract": "The mating pathway in \\emph{Saccharomyces cerevisiae} is one of the best\nunderstood signal transduction pathways in eukaryotes. It transmits the mating\nsignal from plasma membrane into the nucleus through the G-protein coupled\nreceptor and the mitogen-activated protein kinase (MAPK) cascade. According to\nthe current understandings of the mating pathway, we construct a system of\nordinary differential equations to describe the process. Our model is\nconsistent with a wide range of experiments, indicating that it captures some\nmain characteristics of the signal transduction along the pathway.\nInvestigation with the model reveals that the shuttling of the scaffold protein\nand the dephosphorylation of kinases involved in the MAPK cascade cooperate to\nregulate the response upon pheromone induction and to help preserving the\nfidelity of the mating signaling. We explored factors affecting the\ndose-response curves of this pathway and found that both negative feedback and\nconcentrations of the proteins involved in the MAPK cascade play crucial role.\nContrary to some other MAPK systems where signaling sensitivity is being\namplified successively along the cascade, here the mating signal is transmitted\nthrough the cascade in an almost linear fashion.",
"arxiv_id": "q-bio/0609015",
"authors": [
"Danying Shao",
"Wen Zheng",
"Wenjun Qiu",
"Qi Ouyang",
"Chao Tang"
],
"categories": [
"q-bio.MN"
],
"doi": "10.1529/biophysj.106.081661",
"title": "Dynamic Studies of Scaffold-dependent Mating Pathway in Yeast",
"url": "https://arxiv.org/abs/q-bio/0609015"
},
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