{
  "annotation_id": "a41af1a2-3ec9-4591-8a34-6c8e5d80ee88",
  "date_created": "2026-03-02T18:00:53.460000Z",
  "date_modified": "2026-03-02T18:00:53.460000Z",
  "file_hash": "598bfce3c4c801e9a7320254841508f8af56007f78f8cf0ead1727fea0b1cb8d",
  "private": false,
  "record": {
    "abstract": "Model of biological effects of ionizing particles, especially of protons and\nother ions, is proposed. The model is based on distinguishing the\nsingle-particle and collective effects of the underlying radiobiological\nmechanism. The probabilities of individual particles to form severe damages to\nDNA, their synergetic or saturation combinations, and the effect of cellular\nrepair system are taken into account. The model enables to describe linear,\nparabolic and more complex curves, including those exhibiting low-dose\nhypersensitivity phenomena, in a systematic way. Global shape as well as\ndetailed structure of survival curves might be represented, which is crucial if\ndifferent fractionation schemes in radiotherapy should be assessed precisely.\nExperimental cell-survival data for inactivation of V79 cells by low-energy\nprotons have been analyzed and corresponding detailed characteristics of the\ninactivation mechanism have been derived for this case.",
    "arxiv_id": "physics/0411048",
    "authors": [
      "Pavel Kundr\u00e1t",
      "Milo\u0161 Lokaj\u00ed\u010dek",
      "Hana Hrom\u010d\u00edkov\u00e1"
    ],
    "categories": [
      "physics.bio-ph",
      "physics.med-ph",
      "q-bio.QM"
    ],
    "doi": "10.1088/0031-9155/50/7/007",
    "journal_ref": "Phys. Med. Biol. 50 (2005) 1433-1447",
    "title": "Probabilistic two-stage model of cell inactivation by ionizing particles",
    "url": "https://arxiv.org/abs/physics/0411048"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "b30d85d5-34b0-45b7-96ad-042fefb93529",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}