dorsal/arxiv
View SchemaDiversity in Free Energy Landscape of Proteins with the Same Native Topology
| Authors | Hiroo Kenzaki, Macoto Kikuchi |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0512020 |
| URL | https://arxiv.org/abs/q-bio/0512020 |
| DOI | 10.1016/j.cplett.2006.05.112 |
| Journal | Chem. Phys. Lett. 427 (2006) 414-417 |
Abstract
In order to elucidate the role of the native state topology and the stability of subdomains in protein folding, we investigate free energy landscape of human lysozyme, which is composed of two subdomains, by Monte Carlo simulations. A realistic lattice model with Go-like interaction is used. We take the relative interaction strength (stability, in other word) of two subdomains as a variable parameter and study the folding process. A variety of folding process is observed and we obtained a phase diagram of folding in terms of temperature and the relative stability. Experimentally-observed diversity in folding process of c-type lysozimes is thus understood as a consequence of the difference in the relative stability of subdomains.
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"abstract": "In order to elucidate the role of the native state topology and the stability\nof subdomains in protein folding, we investigate free energy landscape of human\nlysozyme, which is composed of two subdomains, by Monte Carlo simulations. A\nrealistic lattice model with Go-like interaction is used. We take the relative\ninteraction strength (stability, in other word) of two subdomains as a variable\nparameter and study the folding process. A variety of folding process is\nobserved and we obtained a phase diagram of folding in terms of temperature and\nthe relative stability. Experimentally-observed diversity in folding process of\nc-type lysozimes is thus understood as a consequence of the difference in the\nrelative stability of subdomains.",
"arxiv_id": "q-bio/0512020",
"authors": [
"Hiroo Kenzaki",
"Macoto Kikuchi"
],
"categories": [
"q-bio.BM",
"cond-mat.soft",
"physics.bio-ph"
],
"doi": "10.1016/j.cplett.2006.05.112",
"journal_ref": "Chem. Phys. Lett. 427 (2006) 414-417",
"title": "Diversity in Free Energy Landscape of Proteins with the Same Native Topology",
"url": "https://arxiv.org/abs/q-bio/0512020"
},
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