{
  "annotation_id": "a2fd7c95-ba3f-4db5-a703-7d0a89d9ac65",
  "date_created": "2026-03-02T18:01:32.275000Z",
  "date_modified": "2026-03-02T18:01:32.275000Z",
  "file_hash": "fc4e4aad085709de9ea995ab3ddff5f4543d5a70e9580caa9379fd52a2e64b46",
  "private": false,
  "record": {
    "abstract": "Experimental observations on synaptic plasticity at individual glutamatergic\nsynapses from the CA3 Shaffer collateral pathway onto CA1 pyramidal cells in\nthe hippocampus suggest that the transitions in synaptic strength occur among\ndiscrete levels at individual synapses (~\\cite{Peter} and S. S.-H. Wang,\nunpublished data used with the authors\u0027 permission). This happens for both long\nterm potentiation (LTP) and long term depression (LTD) induction protocols.\nO\u0027Connor, Wittenberg, and Wang have argued that three states would account for\ntheir observations on individual synapses in the CA3-CA1 pathway. We develop a\nquantitative model of this three state system with transitions among the states\ndetermined by a competition between kinases and phosphatases shown by O\u0027Connor\net al. to be determinant of LTP and LTD, respectively. Specific predictions for\nvarious plasticity protocols are given by coupling this description of discrete\nsynaptic AMPA conductance changes to a model of postsynaptic membrane potential\nand associated intracellular calcium fluxes to yield the transition rates among\nthe states. We then present various LTP and LTD induction protocols to the\nmodel system and report the resulting whole cell changes in AMPA conductance.\nWe also examine the effect of our discrete state synaptic plasticity model on\nthe synchronization of realistic oscillating neurons. We show that one-to-one\nsynchronization is enhanced by the plasticity we discuss here and the\npresynaptic and postsynaptic oscillations are in phase. Synaptic strength\nsaturates naturally in this model and does not require artificial upper or\nlower cutoffs, in contrast to earlier models of plasticity.",
    "arxiv_id": "q-bio/0501026",
    "authors": [
      "H. D. Abarbanel",
      "S. S. Talathi",
      "L. Gibb",
      "M. Rabinovich"
    ],
    "categories": [
      "q-bio.QM",
      "q-bio.NC"
    ],
    "doi": "10.1103/PhysRevE.72.031914",
    "title": "Synaptic Plasticity with Discrete state synapses",
    "url": "https://arxiv.org/abs/q-bio/0501026"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "4cd1ec83-4085-46a4-b394-6ff221016ed8",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}