{
  "annotation_id": "a27620e2-15e8-4525-a82b-1e201307a482",
  "date_created": "2026-03-02T18:01:14.673000Z",
  "date_modified": "2026-03-02T18:01:14.673000Z",
  "file_hash": "84dde4b15625cf220ef7d703983b56ccc53d9591ee019ed7b6429658a6a46357",
  "private": false,
  "record": {
    "abstract": "It is known that the action of general anesthetics is proportional to their\npartition coefficient in lipid membranes (Meyer-Overton rule). This solubility\nis, however, directly related to the depression of the temperature of the\nmelting transition found close to body temperature in biomembranes. We propose\na thermodynamic extension of the Meyer-Overton rule which is based on free\nenergy changes in the system and thus automatically incorporates the effects of\nmelting point depression. This model provides a quantitative explanation of the\npressure reversal of anesthesia. Further, it explains why inflammation and the\naddition of divalent cations reduce the effectiveness of anesthesia.",
    "arxiv_id": "physics/0610147",
    "authors": [
      "Thomas Heimburg",
      "Andrew D. Jackson"
    ],
    "categories": [
      "physics.bio-ph",
      "physics.med-ph"
    ],
    "doi": "10.1529/biophysj.106.099754",
    "journal_ref": "Biophys. J. 92 (2007) 3159-3165",
    "title": "The thermodynamics of general anesthesia",
    "url": "https://arxiv.org/abs/physics/0610147"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "6a3ba5f5-1e4d-41da-95c5-778849024e46",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}