{
  "annotation_id": "a2730f59-c8bc-40e4-835b-8454c00294cc",
  "date_created": "2026-03-02T18:01:35.122000Z",
  "date_modified": "2026-03-02T18:01:35.122000Z",
  "file_hash": "a5266062263d10394f0c0564e8bcd8cb8278c15c0990ee6bf8cc0237a8e1deb1",
  "private": false,
  "record": {
    "abstract": "Using DNA microarray and cluster analysis of expressed genes in a cloned line\n(M1-t-p53) of myeloid leukemic cells, we have analyzed the expression of genes\nthat are preferentially expressed in different normal tissues. Clustering of\n547 highly expressed genes in these leukemic cells showed 38 genes\npreferentially expressed in normal hematopoietic tissues and 122 other genes\npreferentially expressed in different normal non-hematopoietic tissues\nincluding neuronal tissues, muscle, liver and testis. We have also analyzed the\ngenes whose expression in the leukemic cells changed after activation of\nwild-type p53 and treatment with the cytokine interleukin 6 (IL-6) or the\ncalcium mobilizer thapsigargin (TG). Out of 620 such genes in the leukemic\ncells that were differentially expressed in normal tissues, clustering showed\n80 genes that were preferentially expressed in hematopoietic tissues and 132\ngenes in different normal non-hematopietic tissues that also included neuronal\ntissues, muscle, liver and testis. Activation of p53 and treatment with IL-6 or\nTG induced different changes in the genes preferentially expressed in these\nnormal tissues. These myeloid leukemic cells thus express genes that are\nexpressed in normal non-hematopoietic tissues, and various treatments can\nreprogram these cells to induce other such non-hematopoietic genes. The results\nindicate that these leukemic cells share with normal hematopoietic stem cells\nthe plasticity of differentiation to different cell types. It is suggested that\nthis reprogramming to induce in malignant cells genes that are expressed in\ndifferent normal tissues may be of clinical value in therapy.",
    "arxiv_id": "q-bio/0511020",
    "authors": [
      "Joseph Lotem",
      "Hila Benjamin",
      "Dvir Netaneli",
      "Eytan Domany",
      "Leo Sachs"
    ],
    "categories": [
      "q-bio.TO",
      "q-bio.QM"
    ],
    "doi": "10.1073/pnas.0406966101",
    "journal_ref": "PNAS 101, 16022 (2004)",
    "title": "Induction in myeloid leukemic cells of genes that are expressed in   different normal tissues",
    "url": "https://arxiv.org/abs/q-bio/0511020"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "9d9bd9a1-8285-4f82-a1ec-3387542a11ba",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}