{
  "annotation_id": "a25f66e3-035c-4cb8-aa6c-669b5bf9b295",
  "date_created": "2026-03-02T18:00:29.220000Z",
  "date_modified": "2026-03-02T18:00:29.220000Z",
  "file_hash": "9d96299fc1af549e5cf2be38f4f0769049e894210cd35785b403f393cd73edab",
  "private": false,
  "record": {
    "abstract": "We investigate a model of evolutionary dynamics on a smooth landscape which\nfeatures a ``mutator\u0027\u0027 allele whose effect is to increase the mutation rate. We\nshow that the expected proportion of mutators far from equilibrium, when the\nfitness is steadily increasing in time, is governed solely by the transition\nrates into and out of the mutator state. This results is a much faster rate of\nfitness increase than would be the case without the mutator allele. Near the\nfitness equilibrium, however, the mutators are severely suppressed, due to the\ndetrimental effects of a large mutation rate near the fitness maximum. We\ndiscuss the results of a recent experiment on natural selection of E. coli in\nthe light of our model.",
    "arxiv_id": "patt-sol/9711001",
    "authors": [
      "David A. Kessler",
      "Herbert Levine"
    ],
    "categories": [
      "patt-sol",
      "nlin.PS",
      "q-bio.PE"
    ],
    "doi": "10.1103/PhysRevLett.80.2012",
    "title": "Mutator Dynamics on a Smooth Evolutionary Landscape",
    "url": "https://arxiv.org/abs/patt-sol/9711001"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "026c50d9-31d4-427c-a51b-f33ea7aa3668",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}