dorsal/arxiv
View SchemaSome protein interaction data do not exhibit power law statistics
| Authors | Reiko Tanaka, Tau-Mu Yi, John Doyle |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0506038 |
| URL | https://arxiv.org/abs/q-bio/0506038 |
| DOI | 10.1016/j.febslet.2005.08.024 |
| Journal | FEBS Letters 579 (2005) 514--5144 |
Abstract
It has been claimed that protein-protein interaction (PPI) networks are scale-free based on the observation that the node degree sequence follows a power law. Here we argue that these claims are likely to be based on erroneous statistical analysis. Typically, the supporting data are presented using frequency-degree plots. We show that such plots can be misleading, and should correctly be replaced by rank-degree plots. We provide two PPI network examples in which the frequency-degree plots appear linear on a log-log scale, but the rank-degree plots demonstrate that the node degree sequence is far from a power law. We conclude that at least these PPI networks are not scale-free.
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"abstract": "It has been claimed that protein-protein interaction (PPI) networks are\nscale-free based on the observation that the node degree sequence follows a\npower law. Here we argue that these claims are likely to be based on erroneous\nstatistical analysis. Typically, the supporting data are presented using\nfrequency-degree plots. We show that such plots can be misleading, and should\ncorrectly be replaced by rank-degree plots. We provide two PPI network examples\nin which the frequency-degree plots appear linear on a log-log scale, but the\nrank-degree plots demonstrate that the node degree sequence is far from a power\nlaw. We conclude that at least these PPI networks are not scale-free.",
"arxiv_id": "q-bio/0506038",
"authors": [
"Reiko Tanaka",
"Tau-Mu Yi",
"John Doyle"
],
"categories": [
"q-bio.MN"
],
"doi": "10.1016/j.febslet.2005.08.024",
"journal_ref": "FEBS Letters 579 (2005) 514--5144",
"title": "Some protein interaction data do not exhibit power law statistics",
"url": "https://arxiv.org/abs/q-bio/0506038"
},
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