dorsal/arxiv
View SchemaA Selective Advantage for Conservative Viruses
| Authors | Yisroel Brumer, Eugene I. Shakhnovich |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0401022 |
| URL | https://arxiv.org/abs/q-bio/0401022 |
| DOI | 10.1103/PhysRevE.71.031903 |
Abstract
In this letter we study the full semi-conservative treatment of a model for the co-evolution of a virus and an adaptive immune system. Regions of viability are calculated for both conservatively and semi-conservatively replicating viruses interacting with a realistic semi-conservatively replicating immune system. The conservative virus is found to have a selective advantage in the form of an ability to survive in regions with a wider range of mutation rates than its semi-conservative counterpart. This may help explain the existence of a rich range of viruses with conservatively replicating genomes, a trait which is found nowhere else in nature.
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"abstract": "In this letter we study the full semi-conservative treatment of a model for\nthe co-evolution of a virus and an adaptive immune system. Regions of viability\nare calculated for both conservatively and semi-conservatively replicating\nviruses interacting with a realistic semi-conservatively replicating immune\nsystem. The conservative virus is found to have a selective advantage in the\nform of an ability to survive in regions with a wider range of mutation rates\nthan its semi-conservative counterpart. This may help explain the existence of\na rich range of viruses with conservatively replicating genomes, a trait which\nis found nowhere else in nature.",
"arxiv_id": "q-bio/0401022",
"authors": [
"Yisroel Brumer",
"Eugene I. Shakhnovich"
],
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"q-bio.PE",
"cond-mat.soft"
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"doi": "10.1103/PhysRevE.71.031903",
"title": "A Selective Advantage for Conservative Viruses",
"url": "https://arxiv.org/abs/q-bio/0401022"
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