dorsal/arxiv
View SchemaA simple measure of native-state topology and chain connectivity predicts the folding rates of two-state proteins with and without crosslinks
| Authors | Purushottam D. Dixit, Thomas R. Weikl |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0601047 |
| URL | https://arxiv.org/abs/q-bio/0601047 |
Abstract
The folding rates of two-state proteins have been found to correlate with simple measures of native-state topology. The most prominent among these measures is the relative contact order (CO), which is the average CO or 'localness' of all contacts in the native protein structure, divided by the chain length. Here, we test whether such measures can be generalized to capture the effect of chain crosslinks on the folding rate. Crosslinks change the chain connectivity and therefore also the localness of some of the the native contacts. These changes in localness can be taken into account by the graph-theoretical concept of effective contact order (ECO). The relative ECO, however, the natural extension of the relative CO for proteins with crosslinks, overestimates the changes in the folding rates caused by crosslinks. We suggest here a novel measure of native-state topology, the relative logCO, and its natural extension, the relative logECO. The relative logCO is the average value for the logarithm of the CO of all contacts, divided by the logarithm of the chain length. The relative log(E)CO reproduces the folding rates of a set of 26 two-state proteins without crosslinks with essentially the same high correlation coefficient as the relative CO. In addition, it also captures the folding rates of 8 two-state proteins with crosslinks.
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"abstract": "The folding rates of two-state proteins have been found to correlate with\nsimple measures of native-state topology. The most prominent among these\nmeasures is the relative contact order (CO), which is the average CO or\n\u0027localness\u0027 of all contacts in the native protein structure, divided by the\nchain length. Here, we test whether such measures can be generalized to capture\nthe effect of chain crosslinks on the folding rate. Crosslinks change the chain\nconnectivity and therefore also the localness of some of the the native\ncontacts. These changes in localness can be taken into account by the\ngraph-theoretical concept of effective contact order (ECO). The relative ECO,\nhowever, the natural extension of the relative CO for proteins with crosslinks,\noverestimates the changes in the folding rates caused by crosslinks. We suggest\nhere a novel measure of native-state topology, the relative logCO, and its\nnatural extension, the relative logECO. The relative logCO is the average value\nfor the logarithm of the CO of all contacts, divided by the logarithm of the\nchain length. The relative log(E)CO reproduces the folding rates of a set of 26\ntwo-state proteins without crosslinks with essentially the same high\ncorrelation coefficient as the relative CO. In addition, it also captures the\nfolding rates of 8 two-state proteins with crosslinks.",
"arxiv_id": "q-bio/0601047",
"authors": [
"Purushottam D. Dixit",
"Thomas R. Weikl"
],
"categories": [
"q-bio.BM",
"cond-mat.soft"
],
"title": "A simple measure of native-state topology and chain connectivity predicts the folding rates of two-state proteins with and without crosslinks",
"url": "https://arxiv.org/abs/q-bio/0601047"
},
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