dorsal/arxiv
View SchemaSpectral representation: analyzing single-unit activity in extracellularly recorded neuronal data without spike sorting
| Authors | Artur Luczak, Nandakumar S. Narayanan |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0502039 |
| URL | https://arxiv.org/abs/q-bio/0502039 |
Abstract
One step in the conventional analysis of extracellularly recorded neuronal data is spike sorting, which separates electrical signal into action potentials from different neurons. Because spike sorting involves human judgment, it can be subjective and time intensive, particularly for large sets of neurons. Here we propose a simple, automated way to construct alternative representations of neuronal activity, called spectral representation (SR). In this approach, neuronal spikes are mapped to a discrete space of spike- waveform features and time. Spectral representation enables us to find single-unit stimulus related changes in neuronal activity without spike sorting. We tested the ability of this method to predict stimuli using both simulated data and experimental data from an auditory mapping study in anesthetized marmoset monkeys. We find that our approach produces more accurate classification of stimuli than spike sorted data for both simulated and experimental conditions. Furthermore, this method lends itself to automated analysis of extracellularly recorded neuronal ensembles. Additionally, we suggest ways in which these representations can be readily extended to assist in spike sorting and the evaluation of single-neuron peri-stimulus time histograms.
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"abstract": "One step in the conventional analysis of extracellularly recorded neuronal\ndata is spike sorting, which separates electrical signal into action potentials\nfrom different neurons. Because spike sorting involves human judgment, it can\nbe subjective and time intensive, particularly for large sets of neurons. Here\nwe propose a simple, automated way to construct alternative representations of\nneuronal activity, called spectral representation (SR). In this approach,\nneuronal spikes are mapped to a discrete space of spike- waveform features and\ntime. Spectral representation enables us to find single-unit stimulus related\nchanges in neuronal activity without spike sorting. We tested the ability of\nthis method to predict stimuli using both simulated data and experimental data\nfrom an auditory mapping study in anesthetized marmoset monkeys. We find that\nour approach produces more accurate classification of stimuli than spike sorted\ndata for both simulated and experimental conditions. Furthermore, this method\nlends itself to automated analysis of extracellularly recorded neuronal\nensembles. Additionally, we suggest ways in which these representations can be\nreadily extended to assist in spike sorting and the evaluation of single-neuron\nperi-stimulus time histograms.",
"arxiv_id": "q-bio/0502039",
"authors": [
"Artur Luczak",
"Nandakumar S. Narayanan"
],
"categories": [
"q-bio.NC",
"q-bio.QM"
],
"title": "Spectral representation: analyzing single-unit activity in extracellularly recorded neuronal data without spike sorting",
"url": "https://arxiv.org/abs/q-bio/0502039"
},
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