{
  "annotation_id": "9945d716-e13b-4d0c-ba96-ad96c5b897c9",
  "date_created": "2026-03-02T18:00:32.498000Z",
  "date_modified": "2026-03-02T18:00:32.498000Z",
  "file_hash": "a8148df0b5cf417fc9fbda4a279de7eab66c3e98f2776c3cefc9425b67c6ca36",
  "private": false,
  "record": {
    "abstract": "We formulate a kinetic model of DNA replication that quantitatively describes\nrecent results on DNA replication in the in vitro system of Xenopus laevis\nprior to the mid-blastula transition. The model describes well a large amount\nof different data within a simple theoretical framework. This allows one, for\nthe first time, to determine the parameters governing the DNA replication\nprogram in a eukaryote on a genome-wide basis. In particular, we have\ndetermined the frequency of origin activation in time and space during the cell\ncycle. Although we focus on a specific stage of development, this model can\neasily be adapted to describe replication in many other organisms, including\nbudding yeast.",
    "arxiv_id": "physics/0101087",
    "authors": [
      "John Herrick",
      "Suckjoon Jun",
      "John Bechhoefer",
      "Aaron Bensimon"
    ],
    "categories": [
      "physics.bio-ph",
      "q-bio.OT",
      "q-bio.QM"
    ],
    "doi": "10.1016/S0022-2836(02)00522-3",
    "journal_ref": "J.Mol.Biol., 320, 741-750 (2002)",
    "title": "Kinetic model of DNA replication in eukaryotic organisms",
    "url": "https://arxiv.org/abs/physics/0101087"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "84daed1e-a2e6-49d9-b3aa-c489f996a8fe",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}