dorsal/arxiv
View SchemaKinetic model of DNA replication in eukaryotic organisms
| Authors | John Herrick, Suckjoon Jun, John Bechhoefer, Aaron Bensimon |
|---|---|
| Categories | |
| ArXiv ID | physics/0101087 |
| URL | https://arxiv.org/abs/physics/0101087 |
| DOI | 10.1016/S0022-2836(02)00522-3 |
| Journal | J.Mol.Biol., 320, 741-750 (2002) |
Abstract
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition. The model describes well a large amount of different data within a simple theoretical framework. This allows one, for the first time, to determine the parameters governing the DNA replication program in a eukaryote on a genome-wide basis. In particular, we have determined the frequency of origin activation in time and space during the cell cycle. Although we focus on a specific stage of development, this model can easily be adapted to describe replication in many other organisms, including budding yeast.
{
"annotation_id": "9945d716-e13b-4d0c-ba96-ad96c5b897c9",
"date_created": "2026-03-02T18:00:32.498000Z",
"date_modified": "2026-03-02T18:00:32.498000Z",
"file_hash": "a8148df0b5cf417fc9fbda4a279de7eab66c3e98f2776c3cefc9425b67c6ca36",
"private": false,
"record": {
"abstract": "We formulate a kinetic model of DNA replication that quantitatively describes\nrecent results on DNA replication in the in vitro system of Xenopus laevis\nprior to the mid-blastula transition. The model describes well a large amount\nof different data within a simple theoretical framework. This allows one, for\nthe first time, to determine the parameters governing the DNA replication\nprogram in a eukaryote on a genome-wide basis. In particular, we have\ndetermined the frequency of origin activation in time and space during the cell\ncycle. Although we focus on a specific stage of development, this model can\neasily be adapted to describe replication in many other organisms, including\nbudding yeast.",
"arxiv_id": "physics/0101087",
"authors": [
"John Herrick",
"Suckjoon Jun",
"John Bechhoefer",
"Aaron Bensimon"
],
"categories": [
"physics.bio-ph",
"q-bio.OT",
"q-bio.QM"
],
"doi": "10.1016/S0022-2836(02)00522-3",
"journal_ref": "J.Mol.Biol., 320, 741-750 (2002)",
"title": "Kinetic model of DNA replication in eukaryotic organisms",
"url": "https://arxiv.org/abs/physics/0101087"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "84daed1e-a2e6-49d9-b3aa-c489f996a8fe",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}