dorsal/arxiv
View SchemaModulation of Base Specific Mutation and Recombination Rates Enables Functional Adaptation within the Context of the Genetic Code
| Authors | Taison Tan, Leonard D. Bogarad, Michael W. Deem |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0404022 |
| URL | https://arxiv.org/abs/q-bio/0404022 |
Abstract
The persistence of life requires populations to adapt at a rate commensurate with the dynamics of their environment. Successful populations that inhabit highly variable environments have evolved mechanisms to increase the likelihood of successful adaptation. We introduce a $64 \times 64$ matrix to quantify base-specific mutation potential, analyzing four different replicative systems, error-prone PCR, mouse antibodies, a nematode, and Drosophila. Mutational tendencies are correlated with the structural evolution of proteins. In systems under strong selective pressure, mutational biases are shown to favor the adaptive search of space, either by base mutation or by recombination. Such adaptability is discussed within the context of the genetic code at the levels of replication and codon usage.
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"abstract": "The persistence of life requires populations to adapt at a rate commensurate\nwith the dynamics of their environment. Successful populations that inhabit\nhighly variable environments have evolved mechanisms to increase the likelihood\nof successful adaptation. We introduce a $64 \\times 64$ matrix to quantify\nbase-specific mutation potential, analyzing four different replicative systems,\nerror-prone PCR, mouse antibodies, a nematode, and Drosophila. Mutational\ntendencies are correlated with the structural evolution of proteins. In systems\nunder strong selective pressure, mutational biases are shown to favor the\nadaptive search of space, either by base mutation or by recombination. Such\nadaptability is discussed within the context of the genetic code at the levels\nof replication and codon usage.",
"arxiv_id": "q-bio/0404022",
"authors": [
"Taison Tan",
"Leonard D. Bogarad",
"Michael W. Deem"
],
"categories": [
"q-bio.GN",
"q-bio.PE"
],
"title": "Modulation of Base Specific Mutation and Recombination Rates Enables Functional Adaptation within the Context of the Genetic Code",
"url": "https://arxiv.org/abs/q-bio/0404022"
},
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