dorsal/arxiv
View SchemaA Growth Model for Multicellular Tumor Spheroids
| Authors | Pier Paolo Delsanto, Caterina Guiot, Piero Giorgio Degiorgis, Carlos A. Condat, Yuri Mansury, Thomas S. Deisboeck |
|---|---|
| Categories | |
| ArXiv ID | physics/0307136 |
| URL | https://arxiv.org/abs/physics/0307136 |
| DOI | 10.1063/1.1812842 |
Abstract
Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B(m) = mp, the specific value of the exponent p is the object of an ongoing debate, with many mechanisms being postulated to support different predictions. We propose that multicellular tumor spheroids provide an ideal experimental model system for testing these allometric growth theories, especially under controlled conditions of malnourishment and applied mechanical stress.
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"abstract": "Most organisms grow according to simple laws, which in principle can be\nderived from energy conservation and scaling arguments, critically dependent on\nthe relation between the metabolic rate B of energy flow and the organism mass\nm. Although this relation is generally recognized to be of the form B(m) = mp,\nthe specific value of the exponent p is the object of an ongoing debate, with\nmany mechanisms being postulated to support different predictions. We propose\nthat multicellular tumor spheroids provide an ideal experimental model system\nfor testing these allometric growth theories, especially under controlled\nconditions of malnourishment and applied mechanical stress.",
"arxiv_id": "physics/0307136",
"authors": [
"Pier Paolo Delsanto",
"Caterina Guiot",
"Piero Giorgio Degiorgis",
"Carlos A. Condat",
"Yuri Mansury",
"Thomas S. Deisboeck"
],
"categories": [
"physics.bio-ph",
"q-bio"
],
"doi": "10.1063/1.1812842",
"title": "A Growth Model for Multicellular Tumor Spheroids",
"url": "https://arxiv.org/abs/physics/0307136"
},
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"type": "Model",
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