dorsal/arxiv
View SchemaProtein folding rates correlate with heterogeneity of folding mechanism
| Authors | B. Öztop, M. R. Ejtehadi, S. S. Plotkin |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0407022 |
| URL | https://arxiv.org/abs/q-bio/0407022 |
| DOI | 10.1103/PhysRevLett.93.208105 |
Abstract
By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse grained, C-alpha model, Go proteins, we show that folding rates correlate with the degree of heterogeneity in the formation of native contacts. Statistically significant correlations are observed between folding rates and measures of heterogeneity inherent in the native topology, as well as between rates and the variance in the distribution of either experimentally measured or simulated phi-values.
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"abstract": "By observing trends in the folding kinetics of experimental 2-state proteins\nat their transition midpoints, and by observing trends in the barrier heights\nof numerous simulations of coarse grained, C-alpha model, Go proteins, we show\nthat folding rates correlate with the degree of heterogeneity in the formation\nof native contacts. Statistically significant correlations are observed between\nfolding rates and measures of heterogeneity inherent in the native topology, as\nwell as between rates and the variance in the distribution of either\nexperimentally measured or simulated phi-values.",
"arxiv_id": "q-bio/0407022",
"authors": [
"B. \u00d6ztop",
"M. R. Ejtehadi",
"S. S. Plotkin"
],
"categories": [
"q-bio.QM",
"q-bio.BM"
],
"doi": "10.1103/PhysRevLett.93.208105",
"title": "Protein folding rates correlate with heterogeneity of folding mechanism",
"url": "https://arxiv.org/abs/q-bio/0407022"
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