{
  "annotation_id": "948127b5-05c7-4beb-9202-08648caa7603",
  "date_created": "2026-03-02T18:01:31.871000Z",
  "date_modified": "2026-03-02T18:01:31.871000Z",
  "file_hash": "63375300667e78936be61664f8b1b6216f0faacd13b7210e2f3b61373ca28a77",
  "private": false,
  "record": {
    "abstract": "By observing trends in the folding kinetics of experimental 2-state proteins\nat their transition midpoints, and by observing trends in the barrier heights\nof numerous simulations of coarse grained, C-alpha model, Go proteins, we show\nthat folding rates correlate with the degree of heterogeneity in the formation\nof native contacts. Statistically significant correlations are observed between\nfolding rates and measures of heterogeneity inherent in the native topology, as\nwell as between rates and the variance in the distribution of either\nexperimentally measured or simulated phi-values.",
    "arxiv_id": "q-bio/0407022",
    "authors": [
      "B. \u00d6ztop",
      "M. R. Ejtehadi",
      "S. S. Plotkin"
    ],
    "categories": [
      "q-bio.QM",
      "q-bio.BM"
    ],
    "doi": "10.1103/PhysRevLett.93.208105",
    "title": "Protein folding rates correlate with heterogeneity of folding mechanism",
    "url": "https://arxiv.org/abs/q-bio/0407022"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "8e8848e6-5ef3-478a-8e00-c2caf393627e",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}